Results 81 to 90 of about 8,688 (228)

Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy [PDF]

Cochrane Database of Systematic Reviews, 2014
Fuchs endothelial dystrophy (FED) is a condition in which there is premature degeneration of corneal endothelial cells. When the number of endothelial cells is reduced to a significant degree, fluid begins to accumulate within the cornea. As a result, the cornea loses its transparency and the individual suffers a reduction in vision.
Mayank A, Nanavaty, Xue, Wang, Alex J, Shortt   +2 more
openaire   +2 more sources

Presbyopia Correction in Lens Replacement Surgery: A Review

Clinical &Experimental Ophthalmology, Volume 53, Issue 6, Page 668-681, August 2025.
ABSTRACT Presbyopia affects approximately 1.8 billion individuals globally, posing significant challenges as life expectancy and near‐vision demands, particularly with mobile phone use, grow. Addressing presbyopia during lens replacement surgery has become a key focus for cataract surgeons, aiming to reduce dependence on corrective eyewear. This review
Benjamin Stern, Damien Gatinel
wiley   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, Volume 9, Issue 7, July 2025.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Visual outcome of penetrating keratoplasty, deep anterior lamellar keratoplasty and Descemet membrane endothelial keratoplasty [PDF]

, 2017
Purpose: A single-center, cross-sectional study was designed to assess and compare objective and subjective quality of vision of patients intervened with penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK) and Descemet membrane ...
Cardona Torradeflot, Genís, Garrido, Claudia, Güell, Josep L., Pujol Ramo, Jaume   +3 more
core   +4 more sources

Canine corneal endothelial cell analysis using vital dyes and light microscopy

Veterinary Ophthalmology, Volume 28, Issue 4, Page 675-682, July 2025.
Abstract Purpose To evaluate the use of vital dyes and light microscopy for assessing canine corneal endothelial morphology ex vivo. Methods The corneas of 40 canine eyes (n = 20 dogs) enucleated <24 h following euthanasia or death were isolated and flat‐mounted on a slide. Corneal endothelium was stained via 0.25% trypan blue followed by 0.5% alizarin
Yamit Soueid, Shaden Baransy, Yulia Goncharov, Yael Keinan, Lionel Sebbag   +4 more
wiley   +1 more source

Estudio comparativo entre microscopía confocal y microscopía especular en la valoración del endotelio en córneas con distrofia de Fuchs [PDF]

, 2011
La distròfia endotelial de Fuchs es caracteritza per la formació de guttas endotelials i en estadis avançats pot induir edema corneal i pèrdua d'agudesa visual. A diferència del microscopi especular, el microscopi confocal té un disseny que permet evitar
Charafeddin, Wissam, Universitat Autònoma de Barcelona. Departament de Cirurgia, Universitat Autònoma de Barcelona. Facultat de Medicina   +2 more
core   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, Volume 15, Issue 5, Page 822-835, May 2025.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Rho-associated kinase inhibitor eye drop (Ripasudil) transiently alters the morphology of corneal endothelial cells [PDF]

, 2015
PURPOSE: Ripasudil (Glanatec), a selective Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, was approved in Japan in September 2014 for the treatment of glaucoma and ocular hypertension.
Fullwood, Nigel J., Inoue, Ryota, Kinoshita, Shigeru, Koizumi, Noriko, Nakano, Shinichiro, Okazaki, Yugo, Okumura, Naoki   +6 more
core   +1 more source

Therapeutic Application of mRNA for Genetic Diseases

WIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 3, May/June 2025.
Overcoming challenges in mRNA therapeutics for rare genetic diseases, such as protection against degradation and immune clearance, organ targeting, and reducing intracellular immunotoxicity with delivery vehicles and mRNA modifications for effective expression and lifespan.
Paul J. L. Schürmann, Stijn P. E. van Breda Vriesman, Jose A. Castro‐Alpízar, Sander A. A. Kooijmans, Edward E. S. Nieuwenhuis, Raymond M. Schiffelers, Sabine A. Fuchs   +6 more
wiley   +1 more source

The Australian Corneal Graft Registry 2012 Report [PDF]

, 2012
The Australian Corneal Graft Registry (ACGR) opened in May 1985 and thus has now been in operation for over 26 years. However, the census dates for this report was 01/06/2010 for penetrating grafts and 12/10/2011 for lamellar grafts.
Coster, Douglas John, Jones, Victoria J, Keane, Miriam Claire, Loh, Raymond S K, Lowe, Marie Therese, Williams, Keryn Anne   +5 more
core   +1 more source