Results 61 to 70 of about 6,377 (178)

Automated detection and classification of nuclei in immunohistochemical stainings for Fuchs' endothelial corneal dystrophy [PDF]

, 2006
Fuchs’ endothelial corneal dystrophy (FECD) is a degenerative disease that affects the elderly population, and which lacks a unifying pathogenic theory and tangible drug targets.
Janssens, Thomas, De Roo, An-Katrien, Foets, Beatrijs, van den Oord, Joost, Van den Berghe, Greet, Güiza, Fabian   +5 more
core   +2 more sources

High‐Purity Functional Corneal Endothelial Cells From Human Induced Pluripotent Stem Cells via a Novel Wash‐Out Method

MedComm, Volume 7, Issue 4, April 2026.
iPSC‐derived corneal endothelial cells purified via a novel wash‐out method show high functional fidelity, resemble primary CECs, and restore corneal clarity in vivo, offering a scalable alternative to donor transplantation. ABSTRACT Corneal endothelial failure can cause blindness, with transplantation as the only treatment.
Eun‐Ah Ye, Changmin Kim, Minah Jeon, Yeji Yoon, Jiyoon Park, Ryun Hee Lee, Carson Yu, Ho Seok Chung, Jae Yong Kim, David Myung, Hun Lee   +10 more
wiley   +1 more source

Evolving Techniques and Indications of Descemet Membrane Endothelial Keratoplasty

Türk Oftalmoloji Dergisi, 2021
Endothelial keratoplasty has replaced traditional penetrating keratoplasty for the treatment of corneal endothelial dysfunction. It offers faster, more predictable, stable visual recovery and low rejection rates while the surgery itself is less invasive.
Özlem Evren Kemer, Emine Esra Karaca, Silke Oellerich, Gerrit Melles   +3 more
doaj   +1 more source

The Australian Corneal Graft Registry 2007 Report [PDF]

, 2007
The Australian Corneal Graft Registry opened in May 1985 and thus has now been in operation for over 22 years. The census date for this report was 01/09/2006. Over the years, we have collected data on more than 18,500 corneal grafts.
Bartlett, Christine Mary, Coster, Douglas John, Kelly, L, Lowe, Marie Therese, Williams, Keryn Anne   +4 more
core  

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

Retained Descemet’s membrane following penetrating keratoplasty for Fuchs’ endothelial dystrophy: a case report of a post-operative complication

Clinical Ophthalmology, 2013
Katherine McVeigh,1,3,* Kurt Spiteri Cornish,3 Aravind R Reddy,3 Georgios Vakros2,3,* 1Eye Clinic, Royal United Bath Hospital, Bath, UK; 2Birmingham Midland Eye Centre, Birmingham City Hospital, Birmingham, UK; 3Ophthalmology Department, Aberdeen Royal ...
McVeigh K, Spiteri Cornish K, Reddy AR, Vakros G   +3 more
doaj  

Update on the Surgical Management of Fuchs Endothelial Corneal Dystrophy

Ophthalmology and Therapy, 2020
Fuchs endothelial corneal dystrophy (FECD) is the most common posterior corneal dystrophy and the leading indication for corneal transplantation in the United States.
Andrea L. Blitzer, Kathryn A. Colby
doaj   +1 more source

Tips, Tricks, and Guides in Descemet Membrane Endothelial Keratoplasty Learning Curve

Journal of Ophthalmology, 2021
Lamellar keratoplasty is fast becoming the most popular form of corneal transplantation. The adoption of Descemet membrane endothelial keratoplasty (DMEK) in the management of Fuchs endothelial dystrophy and pseudophakic bullous keratopathy is partly ...
Davide Borroni, Carlos Rocha de Lossada, Mohit Parekh, Kunal Gadhvi, Chiara Bonzano, Vito Romano, Hannah J. Levis, Aris Tzamalis, Bernhard Steger, Miguel Rechichi, Marina Rodriguez-Calvo-de-Mora   +10 more
doaj   +1 more source

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

VIEW, Volume 7, Issue 1, February 2026.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang, Yanxia Liu, Xiaole Guo, Zhaorun Li, Ziyu Liu, Shuming Zhang, Yuma Yang, Jun Liu, Shoucheng Ma, Linke Ma, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaoling Ding, Xiaofei Li, Qian Hao, Yanjie You, Tingting Yang, Qingrui Li, Xue Zhang, Sihan Zhang, Hengjun Gao, Shengjuan Hu   +22 more
wiley   +1 more source

Quality of life and participation after corneal transplantation and potential predictors: A multicenter prospective cohort study

Acta Ophthalmologica, Volume 104, Issue 1, Page 52-64, February 2026.
Abstract Purpose To evaluate the long‐term effect of corneal transplantation on health‐ and vision‐related quality of life, visual functioning, and societal participation, and to assess potential predictors. Methods We conducted a multicenter prospective cohort study in 11 Dutch hospitals and eye clinics.
E. B. M. Elsman, D. Van der Meij, H. P. A. Van der Aa, N. Santana, M. C. Bartels, M. Zaal, Y. Y. Cheng, R. M. M. A. Nuijts, G. H. M. B. Van Rens, R. M. A. Van Nispen   +9 more
wiley   +1 more source