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Journal of Functional Biomaterials, 2015 Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision.
Jesintha Navaratnam +2 more
exaly +4 more sources
Research Progress of Polymer Biomaterials as Scaffolds for Corneal Endothelium Tissue Engineering [PDF]
Nanomaterials, 2023 Nowadays, treating corneal diseases arising from injury to the corneal endothelium necessitates donor tissue, but these corneas are extremely scarce. As a result, researchers are dedicating significant efforts to exploring alternative approaches that do ...
Xiaoying Luo, Jie Tao, Yao Li
exaly +4 more sources
Spatiotemporal gene targeting in the mouse corneal endothelium [PDF]
Taiwan Journal of Ophthalmology, 2023 PURPOSE: The inducible Cre-ERT2 recombinase system allows for temporal control of gene targeting, and it is useful to studying adult function of genes that have critical developmental roles.
JeongGoo Lee, Martin Heur
doaj +3 more sources
Chinese Medical Journal, 2018 Background: Endothelium allotransplantation is the primary treatment for corneal decompensation. The worldwide shortage of donor corneal tissue has led to increasing pressure to seek an alternative for surgical restoration of corneal endothelium ...
Yu-Jie Cen, Yun Feng
doaj +2 more sources
Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium [PDF]
Advanced Science, 2022 Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enhancing its ...
Eleonora Maurizi +7 more
doaj +2 more sources
Diseases of the corneal endothelium. [PDF]
Exp Eye Res, 2021 The corneal endothelial monolayer and associated Descemet's membrane (DM) complex is a unique structure that plays an essential role in corneal function. Endothelial cells are neural crest derived cells that rest on a special extracellular matrix and play a major role in maintaining stromal hydration within a narrow physiologic range necessary for ...
Jeang LJ, Margo CE, Espana EM.
europepmc +3 more sources
The Multifarious Effects of Various Glaucoma Pharmacotherapy on Corneal Endothelium: A Narrative Review [PDF]
Ophthalmology and Therapy, 2023 Corneal endothelium is a single cell layer that is mainly responsible for maintaining corneal clarity. Endothelial damage secondary to toxicity, stress, or genetic predisposition are common and in conjunction with the low regenerative ability of the ...
Stylianos A. Kandarakis +6 more
doaj +2 more sources
Tissue engineered corneal endothelium transplantation in an ex vivo human cornea organ culture model [PDF]
Scientific ReportsTransplantation of corneal tissue is the standard treatment for irreversible corneal endothelium decompensation by replacing the malfunctioning corneal endothelial cells and Descemet’s membrane.
Meng-Chen Tsai +2 more
doaj +2 more sources
Tissue Engineering of Corneal Endothelium [PDF]
Journal of Functional Biomaterials, 2012 Human corneal endothelial cells (HCECs) do not replicate after wounding. Therefore, corneal endothelial deficiency can result in irreversible corneal edema. Descemet stripping automated endothelial keratoplasty (DSAEK) allows selective replacement of the diseased corneal endothelium.
Satoru Yamagami +2 more
openaire +4 more sources
Molecular Vision, 2019 Purpose: To determine whether the mouse corneal endothelium enters endothelial to mesenchymal transition (EndoMT) following surgical injury in vivo. Methods: The corneal endothelium in anesthetized mice was surgically injured in vivo under direct ...
JeongGoo Lee, Eric Jung, Martin Heur
doaj +1 more source