Results 1 to 10 of about 161,416 (241)

Research Progress of Polymer Biomaterials as Scaffolds for Corneal Endothelium Tissue Engineering [PDF]

Nanomaterials, 2023
Nowadays, treating corneal diseases arising from injury to the corneal endothelium necessitates donor tissue, but these corneas are extremely scarce. As a result, researchers are dedicating significant efforts to exploring alternative approaches that do ...
Yao Li, Shenmin Zhu, Xiaoying Luo
exaly   +4 more sources

Substrates for Expansion of Corneal Endothelial Cells towards Bioengineering of Human Corneal Endothelium

Journal of Functional Biomaterials, 2015
Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision.
Aboulghassem Shahdadfar, Jesintha Navaratnam, Tor Paaske Utheim   +2 more
exaly   +4 more sources

Spatiotemporal gene targeting in the mouse corneal endothelium. [PDF]

Taiwan J Ophthalmol, 2023
PURPOSE: The inducible Cre-ERT2 recombinase system allows for temporal control of gene targeting, and it is useful to studying adult function of genes that have critical developmental roles.
Lee J, Heur M.
europepmc   +3 more sources

High expression of the underexplored SLC4A11 protein-coding transcript is specific to the corneal endothelium. [PDF]

Sci Rep
Fuchs’ endothelial corneal dystrophy (FECD) and congenital hereditary endothelial dystrophy (CHED) are corneal endothelial pathologies associated with SLC4A11 gene variants.
Kotova ES, Sharova EI, Kovaleva PA, Malyugin BE, Antonova OP, Belodedova AV, Tkachenko IS, Doludin YV, Garmanova TN, Protasov M, Tsedilina TR, Skorodumova LO.   +11 more
europepmc   +2 more sources

Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium. [PDF]

Adv Sci (Weinh), 2022
Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enhancing its ...
Maurizi E, Martella DA, Schiroli D, Merra A, Mustfa SA, Pellegrini G, Macaluso C, Chiappini C.   +7 more
europepmc   +2 more sources

The Multifarious Effects of Various Glaucoma Pharmacotherapy on Corneal Endothelium: A Narrative Review. [PDF]

Ophthalmol Ther, 2023
Corneal endothelium is a single cell layer that is mainly responsible for maintaining corneal clarity. Endothelial damage secondary to toxicity, stress, or genetic predisposition are common and in conjunction with the low regenerative ability of the ...
Kandarakis SA, Togka KA, Doumazos L, Mylona I, Katsimpris A, Petrou P, Kymionis G.   +6 more
europepmc   +2 more sources

Tissue engineered corneal endothelium transplantation in an ex vivo human cornea organ culture model. [PDF]

Sci Rep
Transplantation of corneal tissue is the standard treatment for irreversible corneal endothelium decompensation by replacing the malfunctioning corneal endothelial cells and Descemet’s membrane.
Tsai MC, Kureshi A, Daniels JT.
europepmc   +2 more sources

Characterization of Human Transition Zone Reveals a Putative Progenitor-Enriched Niche of Corneal Endothelium

Cells, 2019
The corneal endothelium regulates corneal hydration to maintain the transparency of cornea. Lacking regenerative capacity, corneal endothelial cell loss due to aging and diseases can lead to corneal edema and vision loss.
Jodhbir Mehta, Viridiana Kocaba, Gary Peh   +2 more
exaly   +3 more sources

Acute effects of ropivacaine hydrochloride on corneal endothelial cell ultrastructure of horses: ex vivo study

Ciência Rural, 2021
: The objective of this study was to evaluate the acute effects of ropivacaine hydrochloride on the corneal endothelium of horses. Forty-eight eyes were obtained from a commercial slaughterhouse and were randomly divided into three groups.
Marcele de Souza Muccillo, Alessandra Fernandez da Silva, Maiara Poersch Seibel, Renata Lima Baptista, Marcela Torikachvili, Michelle Becker Petersen, João Antonio Tadeu Pigatto   +6 more
doaj   +1 more source

Comparison of TCF4 repeat expansion length in corneal endothelium and leukocytes of patients with Fuchs endothelial corneal dystrophy.

PLoS ONE, 2021
Expansion of CTG trinucleotide repeats (TNR) in the transcription factor 4 (TCF4) gene is highly associated with Fuchs Endothelial Corneal Dystrophy (FECD).
Eric D Wieben, Ross A Aleff, Tommy A Rinkoski, Keith H Baratz, Shubham Basu, Sanjay V Patel, Leo J Maguire, Michael P Fautsch   +7 more
doaj   +1 more source