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Fucoidan-based nanoparticles: Preparations and applications
International Journal of Biological Macromolecules, 2022Nanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based nanoparticles and their biomedical applications in the current review. The fucoidan-based nanoparticles
Jayachandran, Venkatesan +2 more
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Anticancer Effects of Fucoidan
2014Recently, there has been an increased interest in the pharmacologically active natural compounds isolated and used for remedies of various kinds of diseases, including cancer. The great deal of interest has been developed to isolate bioactive compounds from marine resources because of their numerous health beneficial effects.
Kalimuthu, Senthilkumar, Se-Kwon, Kim
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Fucoidan: Biological Activity in Liver Diseases
The American Journal of Chinese Medicine, 2020Fucoidan is a type of polysaccharide rich in sulfuric acid groups and is mainly found in brown algae. Due to its extensive biological activities, such as anticoagulant, antitumor, antithrombotic, antiviral, anti-oxidant and enhancing immune function, fucoidan has gradually become a research hotspot.
Jingjing, Li, Chuanyong, Guo, Jianye, Wu
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Fucoidans inhibited tau interaction and cellular uptake
Carbohydrate Polymers, 2023Tau spreading in Alzheimer's disease is mediated by cell surface heparan sulfate (HS). As a class of sulfated polysaccharides, fucoidans might compete with HS to bind tau, resulting in the cessation of tau spreading. The structural determinants of fucoidans for competition with HS binding to tau are not well understood.
Weihua, Jin +8 more
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A fucoidan fraction from Ascophyllum nodosum
Carbohydrate Research, 2001A fucoidan fraction was purified from the brown alga Ascophyllum nodosum. The polysaccharide contained L-fucose and sulfate as the only constituents. Combination of methylation analysis, Smith degradation, FTIR and NMR spectroscopy on the native and the de-sulfated polymers demonstrated that the fucoidan consisted of a highly branched core region with ...
Marais, M.F., Joseleau, J.P.
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Carbohydrate Polymers
Sulfated polysaccharides (SPS) derived from seaweeds are precious bioactive compounds of diverse biological activities. Fucoidan is a complex SPS composed of L-fucose and sulfate groups, can be extracted from brown seaweeds, as well as microbial, insect, plant glycans, and marine invertebrates.
Hamed I, Hamouda +4 more
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Sulfated polysaccharides (SPS) derived from seaweeds are precious bioactive compounds of diverse biological activities. Fucoidan is a complex SPS composed of L-fucose and sulfate groups, can be extracted from brown seaweeds, as well as microbial, insect, plant glycans, and marine invertebrates.
Hamed I, Hamouda +4 more
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Journal of Bioscience and Bioengineering, 2017
Fucoidan is an α-l-fucopyranosyl polymer found in seaweeds with forms that have acetyl and sulfuric modifications and derivatives that are lower and/or diversified, with modifications that have attracted interest as potential bioactive substances. We identified the gene for a fucoidan deacetylase that cleaves acetyl moieties from fucoidan and thereby ...
Tatsuhiko Nagao +5 more
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Fucoidan is an α-l-fucopyranosyl polymer found in seaweeds with forms that have acetyl and sulfuric modifications and derivatives that are lower and/or diversified, with modifications that have attracted interest as potential bioactive substances. We identified the gene for a fucoidan deacetylase that cleaves acetyl moieties from fucoidan and thereby ...
Tatsuhiko Nagao +5 more
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Drug Discovery Today
Fucoidan, a polysaccharide from seaweed, holds promise as a drug delivery system and immune modulator; however, its exact mechanism of action remains unclear. As various carbohydrates play key roles in immune responses by binding to carbohydrate-binding proteins like lectins, fucoidan is hypothesized to interact with immune receptors, potentially ...
Rumana, Ferdushi +5 more
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Fucoidan, a polysaccharide from seaweed, holds promise as a drug delivery system and immune modulator; however, its exact mechanism of action remains unclear. As various carbohydrates play key roles in immune responses by binding to carbohydrate-binding proteins like lectins, fucoidan is hypothesized to interact with immune receptors, potentially ...
Rumana, Ferdushi +5 more
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Macroalgal Fucoidan for Biomedical Applications
2019Fucoidan is considered as “gold from the sea” and it has enormous application in the field of biological and biomedical applications. Fucoidan can be converted into nanoparticles, hydrogels, nanofibers, microsphere and scaffolds for tissue engineering, drug delivery and wound dressing applications.
Jayachandran Venkatesan +3 more
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