Results 31 to 40 of about 877,280 (360)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Fuel Efficiency of Small Aircraft [PDF]

Journal of Aircraft, 1980
There is a basic mismatch between the amount of power installed in small propeller-driven aircraft and that required for efficient cruising, which results from climb performance requirements. It is shown in this paper that there is a way of using excess power for most efficient cruise, the resulting airspeed coming closest to the Gabrielli-von Karman ...
openaire   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Impact of endogenous learning curves on maritime transition pathways

Environmental Research Letters
The maritime industry is a crucial hard-to-abate sector that is expected to depend on high-energy density renewable liquid fuels in the future. Traditionally, decarbonization pathways have been assessed assuming exogenous cost trajectories for renewable ...
Sebastian Franz, Rasmus Bramstoft
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Exploring the role of marketing as a tool to aid smart meter adoption amongst fuel poverty and vulnerable groups [PDF]

, 2013
This study is concerned with exploring the role of marketing as a tool to improve smart meter adoption amongst different fuel poverty groups. The traditional view of marketing is that it is a process by which people and firms get what they require and ...
Lewis, J, Rosborough, J
core  

Model Predictive Control for Energy-Efficient Yaw-Stabilizing Torque Vectoring in Electric Vehicles With Four In-Wheel Motors

IEEE Access, 2023
This paper considers the problem of stabilizing and energy-efficient torque vectoring for electric vehicles with four independent in-wheel motors. In electric vehicles with four in-wheel motors, four electric motors are separately attached to the four ...
Sang Hyuk Kim, Kwang-Ki K. Kim
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Study of Minor Actinides Transmutation in PWR MOX fuel

, 2017
The management of long-lived radionuclides in spent fuel is a key issue to achieve the closed nuclear fuel cycle and the sustainable development of nuclear energy.
Chen, Shengli, Wu, Jingxia, Yuan, Cenxi, Zou, Yaolei   +3 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source