Results 131 to 140 of about 247,607 (305)

Flowing gas, non-nuclear experiments on the gas core reactor [PDF]

Flow tests were conducted on models of the gas core (cavity) reactor. Variations in cavity wall and injection configurations were aimed at establishing flow patterns that give a maximum of the nuclear criticality eigenvalue.
Copper, C. G., Kunze, J. F., Suckling, D. H.   +2 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Experimental investigation of a swept-strut fuel-injector concept for scramjet application [PDF]

Results are presented of an experiment to investigate the behavior at Mach 4 flight conditions of the swept-strut fuel-injector concept employed in the Langley integrated modular scramjet engine design.
Anderson, G. Y., Gooderum, P. B., Reagon, P. G., Russin, W. R.   +3 more
core   +1 more source

Biodiesel Performance within Internal Combustion Engine Fuel System: A Review [PDF]

, 2016
This review paper highlights the tribological performance of biodiesel at contacting surfaces in the fuel delivery system of compression ignition (diesel) engines.
Ghafoor, A., Gregory, O., Khan, Zulfiqar Ahmad, Saeed, Adil   +3 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Numerical Analysis of the Effects of Direct Dual Fuel Injection on the Compression Ignition Engine. [PDF]

ACS Omega, 2020
Muniappan K, Sheshadri S, Duvvuri PP.
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Effect of Timing and Pattern of Fuel Injection on Performance and Emissions of a Diesel Engine in the Low-Temperature Combustion Mode – An Experimental Investigation

Journal of Applied Fluid Mechanics, 2019
This paper deals with experimental investigations on a four-cylinder, four-stroke, direct injection, turbocharged engine to evaluate effects of fuel injection strategies, exhaust gas recirculation (EGR) and intake boost pressure on the low temperature ...
K. Mathivanan, J. M. Mallikarjuna, A. Ramesh   +2 more
doaj  

Some Effects of Air Flow on the Penetration and Distribution of Oil Sprays [PDF]

Tests were made to determine the effects of air flow on the characteristics of fuel sprays from fuel injection valves. Curves and photographs are presented showing the airflow throughout the chamber and the effects of the air flow on the fuel spray ...
Beardsley, E G, Rothrock, A M
core   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source