Results 151 to 160 of about 37,027 (259)

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

A novel strut injector with lateral extruded nozzle for efficient hydrogen mixing in supersonic combustors. [PDF]

Sci Rep
Lajimi RH, Alrasheedi NH, Ghodratallah P, Othayq MM, Sadeq AM, Shaban M, Aich W, Hajlaoui K.   +7 more
europepmc   +1 more source

Decoupling Electronic–Ionic Transport and Catalysis Enables High‐Performance, Chemically Stable Sr‐Free Air Electrodes for High‐Temperature Solid Oxide Cells

Advanced Science, EarlyView.
A Sr‐free air electrode for high‐temperature solid oxide cells is designed by independently tailoring electronic conduction, ionic transport, and surface catalysis using complementary Sr‐free phases and infiltrated nanocatalysts. It delivers performance comparable to state‐of‐the‐art Sr‐containing electrodes while completely suppressing Cr‐induced ...
Ji‐eun Won, Wooseok Lee, Jaehyun Seo, Dogeun Yoon, Ho‐Il Ji, HeeChan Kang, Jun Hyuk Kim, Hwitae Kim, Ji Wan Kim, Jongsup Hong, Kyung Joong Yoon   +10 more
wiley   +1 more source

Investigation of diesel post injection using diesel/biodisel/methanol/DTBP: a path towards ultra-low smoke emissions and improved fuel economy. [PDF]

Sci Rep
Dave H, Chan CK, Sonawane C, Pandey A, Dixit S.   +4 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Multi-Parametric Evaluation of a Novel Benzoylthiourea Derivative as a Combustion Modifier in Diesel-Ethanol Blends Under EGR Conditions. [PDF]

Molecules
Coşman S.
europepmc   +1 more source

From Sourcing to End‐of‐Life: Sustainability Challenges and Opportunities in Organic Bioelectronics

Advanced Science, EarlyView.
Organic bioelectronics bridges biology and electronics using organic mixed ionic/electronic conductors. This Perspective addresses sustainability across the full lifecycle of organic bioelectronic materials and devices, offering a framework to guide material sourcing, synthesis, fabrication, application, and end‐of‐life strategies toward bioelectronic ...
Gwennaël Dufil, Marine Batista, Andrea Bionda, Erica Zeglio   +3 more
wiley   +1 more source

Effect of the Injector Pressure-Building Process on Dynamic Gas Flow Characteristics of a Highly Turbulent Underexpanded Hydrogen Jet from a Single-Hole Cylindrical Injector. [PDF]

ACS Omega
Sang H, Ye Y, Lei Y, Zhu Z, Kou C, Liu X, Qiu T.   +6 more
europepmc   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

A Study on Controlling NH₃ and NO_X Emissions in an Ammonia/Diesel Dual-Fuel Engine Using Response Surface Methodology. [PDF]

ACS Omega
Peng Y, Lei J, Liu S, Cui J, Bi Y, Nie X, Shen L.   +6 more
europepmc   +1 more source