Results 161 to 170 of about 1,479,909 (271)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Experimental investigation on the stable operating range of a two-stroke aviation kerosene engine at idle based on cyclic variation analysis. [PDF]

Sci Rep
Li H, Han Z, Wang J, Li J, Deng B, Hou L, Zuo Z.   +6 more
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Sustainable aviation fuels: a review of atomization, combustion and emission characteristics. [PDF]

Biotechnol Biofuels Bioprod
Abdelmagid AM, Glushkov DO, Sviridenko AS, Pershukov VA.   +3 more
europepmc   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Sustainable biodiesel from Mesua ferrea seed oil using explainable machine learning for engine performance evaluation and emission profiling. [PDF]

Sci Rep
Paramasivam P, Hakami A, Ayanie AG.
europepmc   +1 more source

Green's Functions of Non‐Hermitian Systems at Exceptional Deficiency

Advanced Science, EarlyView.
We analyze the responses of a non‐Hermitian lattice system under the condition of exceptional deficiency (ED), when all bands in the system are formed by exceptional points. Using the frequency domain, we identify novel steady‐state responses that root in the broadband super‐Lorentzian Green's function (GF).
Congwei Lu, Guancong Ma
wiley   +1 more source

Machine learning-driven optimization of performance and emissions in a butanol/diesel CI engine. [PDF]

Sci Rep
Siva Prasad K, Vijaybabu TR, Kiran Kumar G, Srinivasa Rao S, Raju VRK, Nagaraju S, Bhowmik A, Jemal A.   +7 more
europepmc   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Impact of butanol-sunflower oil biodiesel-diesel blends on engine performance, combustion, and after-treatment emissions (DOC + SCR). [PDF]

Sci Rep
Baydır ŞA.
europepmc   +1 more source