Results 41 to 50 of about 106,470 (311)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Computational optimization of fuel supply, syngas composition, and intake conditions for a syngas/diesel RCCI engine

, 2018
By utilizing the promising alternative fuel of syngas, and the syngas/diesel dual-fuel reactivity controlled compression ignition (RCCI) is a potential combustion strategy for internal combustion engines.
Xu, Leilei, Xu, Zhen,, Xu, Guangfu, Li, Yaopeng,, Li, Yaopeng, Lu, Xingcai, Xu, Zhen, Chang, Yachao,, Chang, Yachao, Xu, Guangfu,, Jia, Ming, Jia, Ming,, Lu, Xingcai,, Lund University., Xu, Leilei,   +14 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

PEM fuel cells for the power supply of electronic appliances

, 2004
At the Fraunhofer Institute for Solar Energy Systems ISE we develop customized fuel cell systems based on hydrogen or methanol as fuel. This article describes some scientific approaches for the basic understanding of fuel cells we are taking in terms of ...
Hesselmann, Jan, Zobel, Marco, Hakenjos, Alexander, Schumacher, Jürgen, Pocza, David, Burger, Bruno, Münter, Harald, Hebling, Christopher, Zedda, Mario, Wittstatt, Ursula   +9 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Sustainable Fuel Supply for Very Small Island Transportation: The Potential of Hybrid Renewable Energy and Green Hydrogen

Journal of Marine Science and Engineering
The transition to a low-carbon future necessitates innovative approaches to renewable energy deployment, particularly in the marine environment, where abundant resources remain underutilized.
Evanthia Kostidi, Anna Maria Kotrikla, Artemis Maglara, Theodore Lilas   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Feasibility Research of Underwater Application of Fuel Cell

南方能源建设, 2023
[Introduction] In order to further improve the cruising ability of underwater equipment, the high specific energy electric energy system is the key to the problem.
Yongchao NIU, Yansen CHENG, Haichao CHENG, Xuehai LI   +3 more
doaj   +1 more source