Results 61 to 70 of about 6,982,826 (358)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Zero voltage switching with reduced current stress for LED lighting applications

IET Power Electronics
Lighting systems using light emitting diode (LED) have drawn significant attention across the world. Nevertheless, to maintain a steady light output, these systems necessitate constant current regulators.
Kambhampati Venkata Govardhan Rao, Malligunta Kiran Kumar, B. Srikanth Goud, Ramanjaneya Reddy Udumula, Ch. Rami Reddy, Praveen Kumar Balachandran, Muhammad Ammirrul Atiqi Mohd Zainuri, Suganthi Ramasamy   +7 more
doaj   +1 more source

Mathematical model of full-bridge voltage converter

Proceedings of Tomsk State University of Control Systems and Radioelectronics, 2023
The article presents the equivalent circuits and operation modes of a full-bridge static converter. A presented mathematical model of a voltage converter describes the operation of its elements and provides a study of power transformer magnetization. The results of mathematical and simulation modeling obtained in Matlab/Simulink and OrCAD are compared.
Maxim V. Beykov, Viktor G. Bukreev
openaire   +1 more source

The Effect of Lane Changing on Long-Span Highway Bridge Traffic Loading

, 2012
Bridge Maintenance, Safety, Management, Resilience & Sustainability, Sixth International IABMAS Conference, Stresa, Lake Maggiore, Italy, 8-12 July 2012Maximum loading on long-span bridges typically occurs in congested traffic conditions.
Carey, Colm, B Enright, E OBrien, O\u27Brien, Eugene J., C Carey, O'Brien, Eugene J., Enright, Bernard, C Caprani, Caprani, Colin C.   +8 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Boost Full Bridge Bidirectional DC/DC Converter for Supervised Aeronautical Applications

International Journal of Aerospace Engineering, 2014
The More Electrical Aircraft concept requires electronic devices able to efficiently and safely convert electrical power between different voltage levels. The entire realization of a bidirectional DC/DC converter, from design to validation phase, is here
Alberto Cavallo, Beniamino Guida, Luigi Rubino   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Topology Selection of LLC Resonant Converter Applied in PETT

Kongzhi Yu Xinxi Jishu, 2017
LLC resonant converter is the key part of power electronic traction transformer (PETT), and the choice of its topology is critical. It analyzed the LLC resonant converter with symmetrical half bridge, asymmetrical half bridge and full bridge structure ...
CHEN Jiang, LIU Huadong, HUANG Zihao
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Precast Concrete Elements for Accelerated Bridge Construction Final Report, Volume 1-1. Laboratory Testing of Precast Substructure Components: Boone County Bridge: TR-561, January 2009

, 2009
In July 2006, construction began on an accelerated bridge project in Boone County, Iowa that was composed of precast substructure elements and an innovative, precast deck panel system.

core