Results 151 to 160 of about 16,868 (267)

Global pharmacovigilance reporting: comparative analysis of adverse event obligations across five major regulatory authorities. [PDF]

Front Drug Saf Regul
Bernaus CG, Bournissen ML.
europepmc   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Transitioning regulatory authorities in South Africa: a comparative review of the organisational structure and management practices. [PDF]

J Pharm Policy Pract
Hattingh A, Joubert J, Viljoen M.
europepmc   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Lack of harmonisation in immunological data: challenges in synthesising data during the COVID-19 pandemic. [PDF]

EBioMedicine
Shaver N, Colijn C, Heffernan J, Asamoah GD, Piggott T, Cooper C, Bagheri S, Crawley AM, Kagina BM, Bowdish DME, Langlois MA, Little J.   +11 more
europepmc   +1 more source

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source

'What' and 'How' to Measure in Allergy and Clinical Immunology: A Systematic Review of Core Outcome Sets and Outcome Harmonisation Processes. [PDF]

Clin Exp Allergy
Demidova A, Kiknavelidze N, Purtskhvanidze K, Alieva E, Ebrahimnejad M, Konchina S, Nurmeeva A, Matkovskii I, Elmurzaeva E, Davtian S, Degtyareva N, Drewitz KP, Asmanov A, Banjanin N, Botjes E, Comberiati P, Costa J, Chu DK, Epstein MM, Fedorova L, Galvin AD, Giovannini M, Greenhawt M, Jamalyan KR, Jones CJ, Khaleva E, Knibb RC, Leshem YA, Mack DP, Mafra I, Marchisotto MJ, Mijakoski D, Nurtazina A, Özdemir C, Peroni D, Protudjer JLP, Rodríguez del Río P, Schoos AM, Schopfer AF, Stoleski S, Upton J, van de Veen W, Genuneit J, Boyle RJ, Apfelbacher C, Munblit D.   +45 more
europepmc   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

The African Medicines Agency: historical perspective of its origins, evolution, institutional structure and future prospects. [PDF]

Front Med (Lausanne)
Ismail AJ, Darko DM, Walker S, Salek S.
europepmc   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source