Results 111 to 120 of about 977,147 (296)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Hybrid LSTM-GRU Model for Stock Price Prediction

IEEE Access
The dynamic variation of the stock market plays a crucial role in assessing a country’s economic power and development. Modeling the chaotic fluctuations in stock prices aids investors and traders in uncertain situations by evaluating market ...
Amirfarhad Farhadi, Azadeh Zamanifar, Amir Alipour, Alireza Taheri, Mohammad Asadolahi   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Three-Dimensional Convolutional Neural Network for Ultrasound Surface Echo Detection

Sensors
Ultrasound array imaging frequently employs a coupling medium to facilitate wave transmission from the transducer to the target component. Surface echoes, identified by their high-amplitude peaks, are crucial for determining the Time of Flight (TOF) in ...
Mario Muñoz, Adrián Rubio, Marcelo Larrea, Jorge F. Cruza, Jorge Camacho, Guillermo Cosarinsky   +5 more
doaj   +1 more source

Improved Subcell Model for the Prediction of Braided Composite Response [PDF]

In this work, the modeling of triaxially braided composites was explored through a semi-analytical discretization. Four unique subcells, each approximated by a "mosaic" stacking of unidirectional composite plies, were modeled through the use of layered ...
Cater, Christopher R., Goldberg, Robert K., Kohlman, Lee W., Xinran, Xiao   +3 more
core   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Identification of Static Loads in Wharf Mooring Cables Using the Influence Coefficient Method

Sensors
Directly measuring the mooring cable load while a ship is moored at a wharf poses significant practical challenges. This paper proposes an indirect load measurement method to identify mooring cable static loads based on the Influence Coefficient Matrix ...
Jia Zhou, Changshi Xiao, Langxiong Gan, Bo Jiao, Haojie Pan, Haiwen Yuan   +5 more
doaj   +1 more source

Improvements to ultrasonic imaging with post-processing of full matrix capture data

, 2022
Ce mémoire présente les comparaisons entre les différentes méthodes de reconstruction "Total Focusing Method" (TFM) et des différents algorithmes modifiés qui utilisent les données obtenues avec la "Full Matrix Capture" (FMC) dans le but d'améliorer certains points clés présents dans les méthodes d'imageries, tel que les problèmes de reconstructions en
openaire   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source