Results 41 to 50 of about 9,226,030 (253)

Asymptotic second moment of Dirichlet L-functions along a thin coset

Forum of Mathematics, Sigma
We prove an asymptotic formula for the second moment of central values of Dirichlet L-functions restricted to a coset. More specifically, consider a coset of the subgroup of characters modulo d inside the full group of characters modulo q. Suppose that
Bradford Garcia, Matthew P. Young
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The Problem of Expanding Semantic Fields and Untranslatability at Word-Level

Armenian Folia Anglistika, 2007
The article discusses the issue of untranslatability at the lexical level considering the expansion of the meanings of root words and other elements of word formation as a result of the development of the language.
Grigor Ghazaryan
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The right to life: the moments of origin and loss

Правоприменение, 2022
The subject of the article is the right to life interpretation issue, as well as the definition of the term "life" applicable in the legal field, the study of the problems of establishing of the constitutional right to life realization moment and its ...
O. I. Amelchakov
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Poszukiwanie niejednorodności plastycznej materiału dla całkowicie uplastycznionych cylindrów kołowych, poddanych działaniu obciążeń złożonych

Engineering Transactions, 1990
W pracy poszukuje się takiego rozkładu granicy plastyczności materiału, który umożliwia całkowite uplastycznienie przy wyczerpaniu nośności granicznej kołowych cylindrów grubościennych poddanych działaniu obciążeń złożonych (ciśnienie, niewielki moment ...
Anna DOLLAR, Zdzisława KORDAS
doaj  

Novel loop-diagrammatic approach to QCD θ parameter and application to the left-right model

Journal of High Energy Physics, 2023
When the QCD axion is absent in full theory, the strong CP problem has to be explained by an additional mechanism, e.g., the left-right symmetry. Even though tree-level QCD θ ¯ $$ \overline{\theta} $$ parameter is restricted by the mechanism, radiative ...
Junji Hisano, Teppei Kitahara, Naohiro Osamura, Atsuyuki Yamada   +3 more
doaj   +1 more source