Results 221 to 230 of about 8,603,720 (259)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Automated planning architectures for online adaptive radiotherapy: A narrative review of the ethos and unity/Monaco platforms. [PDF]

J Appl Clin Med Phys
Cui S, Chan MF, Zheng D.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Who Benefited Most? Identifying Parent-Child Dyads With Improved Weight Outcomes in the Feel4Diabetes Study. [PDF]

Pediatr Obes
Vitoratou DI, Karaglani E, Argyropoulou M, Dimakopoulou K, Iotova V, Bazdarska Y, Tankova T, Cardon G, Moreno LA, Rurik I, Torzsa P, Lindström J, Makrilakis K, Manios Y.   +13 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Hide and seek: de novo identification in sugar beet reveals impact of non-autonomous LTR retrotransposons. [PDF]

Mob DNA
Maiwald S, Maiwald F, Heitkam T.
europepmc   +1 more source

The Multi-Author Practical Scoping (MAPS) Model: Practical Guidance for Collaborative Scoping Reviews in Health Professions Education. [PDF]

Clin Teach
Stelling H, Brown M, Boyle A, Higgins C, Burford B, Vance G.   +5 more
europepmc   +1 more source

Deciphering transcriptome complexity via long-read sequencing. [PDF]

Imeta
Xu C, Li J, Yin C, Li K, Wang T, Gao S, Yu Y, Chang C, Wang Y, Tong G, Gong L, Hu W, Chai G, Han Y, Qin Q, Jin S, Zou X, Li B, Zhang T, Conesa A, Wang Y, Wang D.   +21 more
europepmc   +1 more source