Results 71 to 80 of about 211,055 (241)

Does pattern mixture modelling reduce bias due to informative attrition compared to fitting a mixed effects model to the available cases or data imputed using multiple imputation?: a simulation study

BMC Medical Research Methodology, 2018
Background Informative attrition occurs when the reason participants drop out from a study is associated with the study outcome. Analysing data with informative attrition can bias longitudinal study inferences.
Catherine A. Welch, Séverine Sabia, Eric Brunner, Mika Kivimäki, Martin J. Shipley   +4 more
doaj   +1 more source

Regret in Dynamic Decision Problems [PDF]

, 2005
The paper proposes a framework to extend regret theory to dynamic contexts. The key idea is to conceive of a dynamic decision problem with regret as an intra-personal game in which the agent forms conjectures about the behaviour of the various ...
Krähmer, Daniel, Stone, Rebecca
core   +2 more sources

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Explaining the Favorite-Longshot Bias: Is it Risk-Love or Misperceptions? [PDF]

, 2010
The favorite–long shot bias describes the long-standing empirical regularity that betting odds provide biased estimates of the probability of a horse winning: long shots are overbet whereas favorites are underbet.
Snowberg, Erik, Wolfers, Justin
core   +6 more sources

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Multiple Imputation of a Continuous Outcome with Fully Observed Predictors Using TabPFN

Stats
Handling missing data is a central challenge in quantitative research, particularly when datasets exhibit complex dependency structures, such as nonlinear relationships and interactions. Multiple imputation (MI) via fully conditional specification (FCS),
Jerome Sepin
doaj   +1 more source

Learnable Diffusion Framework for Mouse V1 Neural Decoding

Advanced Science, EarlyView.
We introduce Sensorium‐Viz, a diffusion‐based framework for reconstructing high‐fidelity visual stimuli from mouse primary visual cortex activity. By integrating a novel spatial embedding module with a Diffusion Transformer (DiT) and a synthetic‐response augmentation strategy, our model outperforms state‐of‐the‐art fMRI‐based baselines, enabling robust
Kaiwen Deng, Peter S. Schwendeman, Yuanfang Guan   +2 more
wiley   +1 more source

Variability in mortality following caesarean delivery, appendectomy, and groin hernia repair in low-income and middle-income countries: a systematic review and analysis of published data

The Lancet Global Health, 2016
Background: Surgical interventions occur at lower rates in resource-poor settings, and complication and death rates following surgery are probably substantial but have not been well quantified.
Tarsicio Uribe-Leitz, MD, Joshua Jaramillo, BA, Lydia Maurer, BA, Rui Fu, BE, Micaela M Esquivel, MD, Prof. Atul A Gawande, MD, Alex B Haynes, MD, Dr. Thomas G Weiser, MD   +7 more
doaj   +1 more source

European Securitisation : a GARCH model of CDO, MBS and Pfandbrief spreads [PDF]

, 2003
Asset-backed securitisation (ABS) is an asset funding technique that involves the issuance of structured claims on the cash flow performance of a designated pool of underlying receivables.
Jobst, Andreas A.
core