Results 41 to 50 of about 353,613 (251)

Immunohistochemical localization of dentin matrix protein 1 in human dentin

European Journal of Histochemistry, 2009
Dentin matrix protein 1 (DMP1) is a non-collagenous matrix protein with a recognized role in the formation of mineralized tissues such as dentin. The aim of this study was to analyze the distribution of DMP1 in human dentin by means of immunofluorescence
G Orsini, A Ruggeri, A Mazzoni, F Nato, M Falconi, A Putignano, R Di Lenarda, A Nanci, L Breschi   +8 more
doaj   +1 more source

Testing the Clar theory: Cyclic conjugation in some benzo- and naphthaleno-annelated ovalenes [PDF]

Kragujevac Journal of Science, 2014
Cyclic conjugation (assessed by its energy effect) is studied in benzo- and naphthaleno-annelated ovalenes, in which annelation is in positions d and o.
Gutman Ivan, Đurđević Jelena, Gojak-Salimović Sabina   +2 more
doaj   +1 more source

Possible differences in effects on ejaculate morphology between shape and size components of the intromittent membranous part of insect male genitalia: Phylogenetic comparative analyses in Carabidae

Frontiers in Ecology and Evolution, 2022
Male genitalia exhibit extreme morphological diversity among animals, but its diversification mechanism has not been fully elucidated. In insects, the intromittent membranous part has been barely studied.
Kôji Sasakawa
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Fully Selective Synthesis of Spirocyclic-1,2-oxazine N-Oxides via Non-Catalysed Hetero Diels-Alder Reactions with the Participation of Cyanofunctionalysed Conjugated Nitroalkenes

Molecules, 2023
Hetero Diels-Alder (HDA) reactions with the participation of E-2-aryl-1-cyano-1-nitroethenes and methylenecyclopentane were evaluated on the basis of experimental as well as quantumchemical data.
Przemysław Woliński, Agnieszka Kącka-Zych, Aneta Wróblewska, Ewelina Wielgus, Rafał Dolot, Radomir Jasiński   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Improving the Cellular Accumulation of Folate-Conjugated Fully Chemically Modified siRNAs via 3′ Terminal Conjugation

ACS Omega
Folic acid (FA) conjugation is a validated tumor-specific delivery platform for small molecules. Although targeted delivery using FA-conjugated oligonucleotides, such as microRNA and small interfering RNAs (siRNA), has been reported, the performance of FA-conjugated fully chemically modified siRNAa commonly used siRNA platform in clinical studies ...
Keiichi Motosawa, Junko Iwano, Toshimasa Harumoto, Hayato Yabuuchi, Kentaro Hatanaka, Yasuo Koda, Toshiko Kubo, Hiroshi Kodaira, Keiji Uehara   +8 more
doaj   +4 more sources

Application of Selected Multi-Axial Fatigue Criteria on the Results of Proportional Fatigue Experiments [PDF]

Transactions of the VŠB-Technical University of Ostrava, Mechanical Series, 2011
The paper describes the experimental results obtained for the combined loading of the specimens in the region of high-cycle fatigue. The specimens were manufactured from common structural steel 11523.1, melt T31052.
František FOJTÍK, Pavel MACURA, Radim HALAMA   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source