Fulvestrant-induced toxic epidermal necrolysis [PDF]
Anais Brasileiros de Dermatologia, 2019 Toxic epidermal necrolysis is a condition with massive keratinocyte apoptosis, and it is associated with high mortality rates. Fulvestrant, an estrogen receptor antagonist, is indicated in the treatment of estrogen receptor-positive metastatic breast ...
Macarena Morales-Conde +3 more
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Fulvestrant in the treatment of luminal metastatic breast cancer: the balance of effectiveness and safety [PDF]
Медицинский совет, 2020 The review presents the results of studies of fulvestrant in metastatic breast cancer (MBC). Hormone therapy is an effective method of treating hormone-positive metastatic breast cancer even in the presence of visceral metastases in the absence of a ...
I. A. Koroleva, M. V. Kopp
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A method to detect fulvestrant interference in estradiol in breast cancer patients [PDF]
Endocrine Connections, 2023 Background: Fulvestrant resembles estradiol in its structure. Reports have been published concerning fulvestrant measured as estradiol by the immunoassays. This may induce falsely elevated estradiol results and wrongly impact medical decisions.
Margarida Brito +2 more
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Silencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo. [PDF]
PLoS ONE, 2013 Pure anti-estrogen fulvestrant has been shown to be a promising ER antagonist for locally advanced and metastatic breast cancer. Unfortunately, a significant proportion of patients developed resistance to this type of endocrine therapy but the molecular ...
Lijiang Zhang +5 more
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Cost-effectiveness of inavolisib-based therapy in PIK3CA-mutated advanced breast cancer in the USA [PDF]
BreastPurpose: Inavolisib plus palbociclib and fulvestrant has been approved for treating PIK3CA-mutated, hormone receptor-positive human epidermal growth factor receptor 2-negative (HR + HER2-), advanced breast cancer in the USA. This study evaluated the cost-
Shixian Liu +5 more
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Cancer Management and Research, 2018 Tingting Zhang,1,* Fubin Feng,2,* Wenge Zhao,3 Yan Yao,3 Jinhui Tian,4 Chao Zhou,2 Chuanxin Zang,1 Cun Liu,1 Xue Wang,5 Changgang Sun2,6 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong ...
Zhang T +9 more
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BRD4 PROTAC degrader enhances fulvestrant sensitivity in ER+ breast cancer via super-enhancer associated GREB1 [PDF]
Frontiers in OncologyBackgroundBreast cancer has the highest incidence and mortality among all cancers affecting women. Fulvestrant resistance remains a major clinical challenge that limits the efficacy of endocrine therapies.
Xiulei Zhang +6 more
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CDK4/6 inhibitors combined with fulvestrant for the treatment of HR+/HER2–advanced or metastatic breast cancer: a Bayesian network meta-analysis [PDF]
BMC CancerBackground This study aimed to assess the efficacy and safety of different CDK4/6 inhibitors combined with fulvestrant in treating HR+/HER2– advanced or metastatic breast cancer, using a Bayesian network meta-analysis.
Yanmin Deng +3 more
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Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1
Pharmacogenomics and Personalized Medicine, 2011 Vineetha Koroth Edavana1, Xinfeng Yu1, Ishwori B Dhakal1, Suzanne Williams1, Baitang Ning2, Ian T Cook3, David Caldwell1, Charles N Falany3, Susan Kadlubar11Division of Medical Genetics, College of Medicine, University of Arkansas for Medical Sciences ...
Edavana VK +8 more
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Insulin-like growth factor-binding protein-3 is induced by tamoxifen and fulvestrant and modulates fulvestrant response in breast cancer cells [PDF]
Frontiers in OncologyIntroductionInsulin-like growth factor binding protein-3 (IGFBP-3) exerts varying effects on estrogen receptor alpha (ERα)-positive and triple-negative breast cancer (TNBC) cells. In ERα-positive cells, IGFBP-3 is antiproliferative and proapoptotic.
Keenan L. Flynn +4 more
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