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Syntheses of Fumagillin and Ovalicin [PDF]

Chemistry - A European Journal, 2010
AbstractThis review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of this family that are known angiogenesis inhibitors. These compounds are comprised of a cyclohexane framework, two epoxides, and five or six contiguous stereogenic centers.
Yujiro Hayashi, Junichiro Yamaguchi
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Fumagillin in Amebiasis

The American Journal of Tropical Medicine and Hygiene, 1952
Summary Fumagillin, orally, is active directly against E. histolytica in macaques and man. In man, at a total dosage of 100 mgm. over 12½ days, 9 of 10 cyst passers remained clear during 3 months; 50 mgm. total cleared only 4 of 10 patients. In monkeys, total dosage of 250–625 mgm./Kg.
H H, ANDERSON, A K, HRENOFF, J V D, ANDERSON, M, NAKAMURA, A N, CONTOPOULOS   +4 more
openaire   +2 more sources

Stability of Dicyclohexylamine and Fumagillin in Honey

Food Chemistry, 2015
Fumagillin is extensively used to control nosema disease in apiculture. In the commercial formulation, fumagillin is present as a salt in an equimolar quantity with dicyclohexylamine (DCH). In this study DCH was observed to be significantly more resistant to degradation in honey than fumagillin using LC-MS/MS analysis.
Stephen F Pernal, Thomas S Thompson, Johan P van den Heever   +2 more
exaly   +3 more sources

The Effect of Dicyclohexylamine and Fumagillin on Nosema ceranae-Infected Honey Bee (Apis mellifera) Mortality in Cage Trial Assays

Apidologie, 2016
International audienceAbstractBoth commercially available fumagillin-based treatments for honey bees (Apis mellifera), Fumagilin-B® as well as Fumidil-B®, contain the reportedly genotoxic and tumorigenic compound dicyclohexylamine (DCH) as the counter ...
Stephen F Pernal, Simon J G Otto, Abdullah Ibrahim   +2 more
exaly   +2 more sources

TREATMENT OF AMEBIASIS WITH FUMAGILLIN

Journal of the American Medical Association, 1954
In his article, "The Use of Fumagillin in Amebiasis," Anderson1has pointed out that in 1949, Hanson and Eble2isolated from Aspergillus fumigatus a crystalline substance consisting exclusively of carbon, hydrogen, and oxygen, and which they named fumagillin. McCowen, Callender, and Lawlis3demonstrated the direct amebacidal effect of this substance.
openaire   +2 more sources

Fumagillin Treatment of Intestinal Microsporidiosis

New England Journal of Medicine, 2002
Intestinal microsporidiosis due to Enterocytozoon bieneusi is a cause of chronic diarrhea, malabsorption, and wasting in immunocompromised patients. Currently, there is no effective treatment.We conducted a randomized, double-blind, placebo-controlled trial of fumagillin (60 mg per day orally for two weeks) in patients with chronic E.
Jean-Michel, Molina, Muriel, Tourneur, Claudine, Sarfati, Sylvie, Chevret, Amaury, de Gouvello, Jean-Gérard, Gobert, Suna, Balkan, Francis, Derouin   +7 more
openaire   +2 more sources

FUMAGILLIN

Reactions Weekly, 2013
openaire   +2 more sources

Total synthesis of (+-)-fumagillin

Journal of the American Chemical Society, 1972
E J, Corey, B B, Snider
openaire   +2 more sources

FUMAGILLIN

1975
Jasjit S. Bindra, Ranjna Bindra
openaire   +1 more source

The Treatment of Amebiasis with Fumagillin

Science, 1952
J H, KILLOUGH, G B, MAGILL, R C, SMITH
openaire   +2 more sources