Results 21 to 30 of about 291 (129)

Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism

British Journal of Cancer, 2023
AbstractFumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years have passed since its discovery as the leading cause of the cancer syndrome Hereditary leiomyomatosis and Renal Cell Carcinoma (HLRCC), it is still unclear how the loss of FH
Lorea Valcarcel-Jimenez, Christian Frezza   +1 more
openaire   +2 more sources

Identification of a Difluorinated Alkoxy Sulfonyl Chloride as a Novel Antitumor Agent for Hepatocellular Carcinoma through Activating Fumarate Hydratase Activity

Pharmaceuticals, 2023
Fenofibrate is known as a lipid-lowering drug. Although previous studies have reported that fenofibrate exhibits potential antitumor activities, IC50 values of fenofibrate could be as high as 200 μM. Therefore, we investigated the antitumor activities of
Jin Jin, Xujun Liang, Wu Bi, Ruijie Liu, Sai Zhang, Yi He, Qingming Xie, Shilei Liu, Ji-Chang Xiao, Pengfei Zhang   +9 more
doaj   +1 more source

Fumarate Hydratase Variants and Their Association With Paraganglioma/Pheochromocytoma

Urology, 2023
To clarify the link between germline variants in fumarate hydratase (FH), hereditary leiomyomatosis and renal cell cancer (HLRCC), and paraganglioma (PGL) and pheochromocytoma (PCC) we utilize a well-annotated hereditary cancer testing database.Records of 120,061 patients receiving germline testing were obtained.
Shirin Zavoshi, Eric Lu, Paul C. Boutros, Liying Zhang, Avital Harari, Kathryn E. Hatchell, Sarah M. Nielsen, Edward D. Esplin, Karen Ouyang, Keith Nykamp, Blake Wilde, Heather Christofk, Brian Shuch   +12 more
openaire   +2 more sources

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Cell Reports, 2019
Summary: The plasticity of a preexisting regulatory circuit compromises the effectiveness of targeted therapies, and leveraging genetic vulnerabilities in cancer cells may overcome such adaptations.
Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher A. Bristow, Alessandro Carugo, Norma Rogers, Paul Leonard, Qing Chang, Robert Mullinax, Jing Han, Xi Shi, Sahil Seth, Brooke A. Meyers, Meredith Miller, Lili Miao, Xiaoyan Ma, Ningping Feng, Virginia Giuliani, Mary Geck Do, Barbara Czako, Wylie S. Palmer, Faika Mseeh, John M. Asara, Yongying Jiang, Pietro Morlacchi, Shuping Zhao, Michael Peoples, Trang N. Tieu, Marc O. Warmoes, Philip L. Lorenzi, Florian L. Muller, Ronald A. DePinho, Giulio F. Draetta, Carlo Toniatti, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek   +37 more
doaj   +1 more source

Fumarate Hydratase v1

, 2020
Fumarate hydratase is a TCA enzyme which converts fumarate to malate (E.C. 4.2.1.2). Here we are assaying the color in the reverse reaction as fumarate accumulates at OD250.
Kimberly Chapman, Parith Wongkittichote
openaire   +1 more source

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Molecular & Cellular Oncology, 2019
Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle ...
Luca Drusian, Alessandra Boletta
doaj   +1 more source

Hereditary Leiomyomatosis and Renal Cell Cancer: Recent Insights Into Mechanisms and Systemic Treatment

Frontiers in Oncology, 2021
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare autosomal dominant hereditary cancer syndrome characterized by a predisposition to cutaneous leiomyomas, uterine leiomyomas, and renal cell carcinoma (RCC).
Congwang Zhang, Lijun Li, Yipeng Zhang, Changchun Zeng   +3 more
doaj   +1 more source

Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma

Case Reports in Oncology, 2023
Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms.
Anjum Othman, Shiyam Kumar, Asim Qureshi, Zabah M. Jawa, Ikram A. Burney   +4 more
doaj   +1 more source

Hereditary Leiomyomatosis and Renal Cell Cancer-Recognizing Patterns May Save Lives

Journal of Kidney Cancer and VHL, 2022
In 2001, Finish investigators described a rare familiar syndrome characterized by an inherited susceptibility to cutaneous leiomyomas, uterine leiomyomas, and renal cell carcinoma (RCC).
Catarina Tavares, Maria Sofia Quental, José Ricardo Brandão, Miguel Silva-Ramos   +3 more
doaj   +3 more sources

Whole-Exome Sequencing Revealed a Pathogenic Germline Variant in the Fumarate Hydratase Gene, Leading to the Diagnosis of Hereditary Leiomyomatosis and Renal Cell Cancer

Diagnostics
The diagnosis of hereditary skin tumors is difficult for “old” diagnostic tools such as immunohistochemistry. Whole-exome sequencing analysis as a “new” diagnostic tool enables us to make a final diagnosis in spite of unknown hereditary diseases in the ...
Akari Nagashima, Sohshi Morimura, Toshihisa Hamada, Takayuki Shiomi, Ichiro Mori, Naoko Sato, Junko Nomoto, Masaki Tanaka, Shoji Tsuji, Makoto Sugaya   +9 more
doaj   +1 more source