Results 31 to 40 of about 291 (129)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

FH-deficient uterine leiomyoma: A rare case report highlighting diagnostic and clinical challenges

Radiology Case Reports
Fumarate hydratase (FH)–deficient uterine leiomyomas are a rare subtype of fibroids with distinctive histological and immunohistochemical features. We report the case of a 44-year-old nulligravida presenting with chronic pelvic pain for 2 years and an ...
Wissal Jaafar, MD, Yasmine Chiba, Malak Medemagh, Souha Gabbouj, Mehdi Bouassida, Nahed Khalifa, Imen Ganzoui, Mechaal Mourali   +7 more
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Characterisation of the fumarate hydratase repertoire in Trypanosoma cruzi

International Journal of Biological Macromolecules, 2017
Nifurtimox and benznidazole represent the only treatments options available targeting Chagas disease, the most important parasitic infection in the Americas. However, use of these is problematic as they are toxic and ineffective against the more severe stages of the disease.
de Pádua, RAP, Kia, AM, Costa-Filho, AJ, Wilkinson, SR, Nonato, MC   +4 more
openaire   +3 more sources

Fumarate Hydratase Mutations and Alterations in Leiomyoma With Bizarre Nuclei [PDF]

International Journal of Gynecological Pathology, 2018
Leiomyoma with bizarre nuclei (LM-BN), is a variant of uterine smooth muscle tumor with atypical histologic features. Although some LM-BN share several significant genetic alterations with leiomyosarcoma, including p16 and p53, the underlying tumorigenesis of LM-BN remains largely unknown. As we previously reported, LM-BN can be divided into 2 subtypes,
Qing, Zhang, Kate, Poropatich, Julianne, Ubago, Jia, Xie, Xiuhua, Xu, Norma, Frizzell, Julie, Kim, Beihua, Kong, Jian-Jun, Wei   +8 more
openaire   +2 more sources

A novel classification of testicular sex cord‐stromal tumours from the Testicular Sex Cord‐Stromal Tumour (TESST) group: a collaboration of the Genitourinary Pathology Society (GUPS) and the International Society of Urological Pathology (ISUP)

Histopathology, EarlyView.
The TESST classification of testicular sex cord‐stromal tumours was agreed upon by consensus based on the best available evidence. The picture shows the members of the TESST group and delegates of GUPS and ISUP present in‐person at the first meeting of the group held at Johns Hopkins Hospital (Baltimore, 2024). Aims Testicular sex cord‐stromal tumours (
Andres M. Acosta, Felix Bremmer, John C. Cheville, Maurizio Colecchia, Eva Comperat, Kristine Cornejo, Dilek E. Baydar, Anthony J. Gill, Maria del Pilar Gonzalez‐Peramato, Sounak Gupta, Michelle S. Hirsch, Muhammad T. Idrees, Chia‐Sui Kao, Fiona MacLean, Andres Matoso, Rohit Mehra, Santosh Menon, Kvetoslava Michalova, Sambit K. Mohanty, Miguel Reyes‐Mugica, Maria Rosaria Raspollini, Ankur R. Sangoi, Lynette M. Sholl, Stephanie Siegmund, Satish K. Tickoo, Toyonori Tsuzuki, Thomas M. Ulbright, Sean R. Williamson, Asli Yilmaz, Daniel M. Berney   +29 more
wiley   +1 more source

Cutaneous and uterine leiomyomatosis and ovarian cystadenoma associated with deficiency of fumerate hydratase

Dermatology Practical & Conceptual, 2011
We report on an exceedingly rare case of cutaneous and uterine leiomyomatosis in a 58-year-old Caucasian woman associated with ovarian cystadenoma and complete deletion of the fumarate hydratase gene.
Cornelia Hüller, Norbert Grunow, Torsten Nadler, Michael Bär   +3 more
doaj   +1 more source

Cutaneous Leiomyosarcoma of the Skin: An Updated Review of Epidemiology, Pathogenesis, and Management

International Journal of Dermatology, EarlyView.
This review provides an update on the epidemiology, pathogenesis, and clinical/histologic features of cutaneous leiomyosarcoma. Prognostic factors (e.g., depth of tumor involvement, grade, etc.) that can facilitate risk stratification are also discussed, as are treatment approaches for this rare malignancy.
Tejas P. Joshi, Natalie Garcia, Malak Husseinali, Nabeeha Engineer, Ikue Shimizu   +4 more
wiley   +1 more source

Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver

Chinese Journal of Cancer, 2016
Cancer metabolism and epigenetic alteration are two critical mechanisms for tumorigenesis and cancer progression; however, the dynamic interplay between them remains poorly understood.
Shuang Liu, Yong-Guang Tao
doaj   +1 more source

Biochemical characterization and essentiality of Plasmodium fumarate hydratase [PDF]

, 2017
ABSTRACT Plasmodium falciparum (Pf), the causative agent of malaria has an iron-sulfur cluster-containing class I fumarate hydratase (FH) that catalyzes the interconversion of fumarate to malate, a well-known reaction in the tricarboxylic acid cycle. In humans, the same reaction is catalyzed by class
Jayaraman, Vijay, Suryavanshi, Arpitha, Kalale, Pavithra, Kunala, Jyothirmai, Balaram, Hemalatha   +4 more
openaire   +2 more sources