Results 51 to 60 of about 291 (129)

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death

Phytotherapy Research, Volume 40, Issue 8, Page 5119-5131, August 2026.
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi, Renda Chahna, Francesca Maffei, Alma Martelli, Vincenzo Calderone, Carmela Fimognari, Eleonora Turrini   +6 more
wiley   +1 more source

Putative Mechanisms for Initial Reaction of Anaerobic Benzene Degradation Presumably Involving a Flavoprotein

Environmental Microbiology, Volume 28, Issue 8, August 2026.
Anaerobic biodegradation of benzene by sulphate‐reducing strain BzS1 was studied by combining genomics, differential proteomics and targeted metabolite analyses. Strain BzS1 has an exceptionally streamlined metabolism. A highly abundant heterotrimeric flavoprotein may add benzene to either enolpyruvate or glutaconyl‐CoA followed by channelling into the
Florin Musat, Lars Wöhlbrand, Rene Jarling, Michael Kube, Niculina Musat, Patrick Becker, Stefan Bruns, Richard Reinhardt, Rudolf Amann, Friedrich Widdel, Heinz Wilkes, Ralf Rabus   +11 more
wiley   +1 more source

Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1403-1413, July 2026.
Objective Our study objective was to identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA (Arthritis Prevention In the Preclinical Phase of RA with Abatacept) study participants were selected from baseline to RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Bilateral fumarate hydratase deficient renal cell carcinoma in a patient with hereditary leiomyomatosis and renal cell cancer syndrome

IJU Case Reports
Introduction Patients with hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome have high risks of uterine and cutaneous leiomyomas and renal cell carcinoma (RCC), which are caused by germline mutation of the fumarate hydratase (FH) gene. RCC
Akihiro Ono, Masaki Nakamura, Takuya Takada, Sakiko Miura, Ibuki Tsuru, Taro Izumi, Masashi Kusakabe, Sachiko Mitarai, Yoji Nagashima, Haruki Kume, Teppei Morikawa, Yoshiyuki Shiga   +11 more
doaj   +1 more source

Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity [PDF]

Journal of the American Chemical Society, 2015
Development of cell-permeable small molecules that target enzymes involved in energy metabolism remains important yet challenging. We describe here the discovery of a new class of compounds with a nutrient-dependent cytotoxicity profile that arises from pharmacological inhibition of fumarate hydratase (also known as fumarase).
Takeuchi, Toshifumi, Schumacker, Paul T., Kozmin, Sergey A.   +2 more
openaire   +2 more sources

Retroperitoneal lymph‐node dissection for isolated nodal recurrence of renal cell carcinoma after nephrectomy: Contemporary outcomes of a case series

BJUI Compass, Volume 7, Issue 7, July 2026.
Abstract Background and objective Isolated retroperitoneal lymph‐node (RPLN) recurrence after radical nephrectomy (RN) for renal cell carcinoma (RCC) is uncommon, and optimal management remains undefined. This study reports contemporary outcomes of retroperitoneal lymph‐node dissection (RPLND) for isolated nodal recurrence, including in patients ...
Alberto Costa Silva, Noel Clarke, Aziz Gulamhusein   +2 more
wiley   +1 more source

Benign Metastasizing Leiomyoma With Myomatous Erythrocytosis Syndrome: First Reported Coexistence as a Unified Hormonal Syndrome

Respirology Case Reports, Volume 14, Issue 7, July 2026.
Time course of haemoglobin (red, left axis) and serum erythropoietin (blue, right axis) before and after hysterectomy with bilateral salpingo‐oophorectomy (BSO, green vertical line, 31 July 2025), showing normalization of both parameters following tumour resection.
Venkatkiran Kanchustambham, Ashley McWalter, Oluwatobi E. Odetola, Recep Nigdelioglu   +3 more
wiley   +1 more source

Diagnosis of Hereditary Leiomyomatosis and Renal Cell Cancer After Subcapsular Renal Hematoma

IJU Case Reports
Introduction Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal dominant genetic disorder. We report a case diagnosed with HLRCC following a subcapsular renal hematoma caused by a tumor. Case Presentation A 28‐year‐old woman with
Kazuma Soya, Takeru Fujimoto, Daisuke Takahashi, Kana Kohashiguchi, Yusuke Takei, Yoshio Sugino, Hiroshi Iwamura   +6 more
doaj   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, Volume 49, Issue 7, Page 3543-3559, July 2026.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases

Indian Journal of Medical and Paediatric Oncology
Introduction Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare, molecularly defined renal tumor with aggressive behavior.
Aswathy A. Menon, Swapnil Rane, Uma Sakhadeo, Gagan Prakash, Amit Joshi, Mahendra Pal, Amandeep Arora, Nilesh Sable, Aparna Katdare, Palak Popat, Priyamvada Maitre, Archi Agarwal, Vedang Murthy, Sangeetha B. Desai, Santosh Menon   +14 more
doaj   +1 more source