Results 71 to 80 of about 291 (129)

DisABLing Kidney Cancers Caused by Fumarate Hydratase Mutations [PDF]

Cancer Cell, 2014
Reprogramming of cellular metabolism by oncogenic mutations probably creates specific vulnerabilities that could be exploited therapeutically. In this issue of Cancer Cell, Sourbier and colleagues show that kidney cancers lacking fumarate hydratase display increased sensitivity to agents that interfere with their ability to cope with reactive oxygen ...
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The emerging role of fumarate as an oncometabolite

Frontiers in Oncology, 2012
The drive to understand how altered cellular metabolism and cancer are linked has caused a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic enzyme, isocitrate dehydrogenase 1 (IDH1), that leads to accumulation of the ...
Ming eYang, Tomoyoshi eSoga, Patrick John Pollard, Julie eAdam   +3 more
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Mechanism by which SUGT1 downregulates FH to promote proliferation and migration in serous ovarian cancer

Journal of Ovarian Research
Background SUGT1 (Suppressor of the G2 allele of SKP1) and FH (fumarate hydratase) have recently garnered significant attention from the research community.
Tianli Mu, Bo Ren, Ziteng Kuang, Runze He, Bingjie Rui, Ye Yang, Yuxi Liu, Danbo Geng, Yuci Zhang, Min Wang   +9 more
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Biochemical characterization of the FH variant p.Lys414Glu reveals loss of enzymatic function and disrupted multimerization

Molecular Genetics and Metabolism Reports
Variants of uncertain significance (VUS) in fumarate hydratase (FH) complicate the diagnosis of hereditary leiomyomatosis and renal cell carcinoma (HLRCC).
Connor J. Huck, Isabella Devaprasad, Blake R. Wilde   +2 more
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Fumarate Hydratase Deficiency and Cancer: Activation of Hypoxia Signaling? [PDF]

Cancer Cell, 2007
Molecular genetic analysis of hereditary leiomyomatosis and renal cell cancer (HLRCC) unexpectedly revealed germline defects in the gene encoding the Krebs cycle enzyme fumarate hydratase (FH), stimulating great interest in the underlying mechanism of oncogenesis.
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Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia

Nature Communications
Staphylococcus aureus is a leading cause of healthcare-associated pneumonia, contributing significantly to morbidity and mortality worldwide. As a ubiquitous colonizer of the upper respiratory tract, S.
Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri, Zhe Liu, Ridhima Wadhwa, Gustavo Rios, Henning Henschel, Nupur Tyagi, Françios A. B. Olivier, Ian R. Monk, Shivang S. Shah, Shwetha H. Sridhar, Marija Drikic, Colleen Bianco, Gaurav K. Lohia, Ayesha Z. Beg, Paul J. Planet, Ian A. Lewis, Robert Sebra, Ana Traven, Abderrahman Hachani, Timothy P. Stinear, Benjamin P. Howden, Jeffrey M. Boyd, Sebastian A. Riquelme, Chu Wang, Alice Prince, Tania Wong Fok Lung   +28 more
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Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Syndrome

Journal of the Belgian Society of Radiology
In hereditary leiomyomatosis and renal cell carcinoma syndrome, fumarate hydratase–deficient renal cell carcinomas typically present as aggressive, unilateral, often cystic masses with heterogeneous enhancement. These tumors can metastasize early, making
Karel Mercken, Brecht Van Berkel, Liesbeth De Wever   +2 more
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Oncometabolite fumarate facilitates PD-L1 expression and immune evasion in clear cell renal cell carcinoma

Cell Death and Disease
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), with a rising incidence worldwide. However, the mechanisms by which ccRCC evades immune surveillance remain incompletely understood.
Yi Gao, Shiyin Fan, Xue Sun, Jiaxi Li, Yue Dai, Hongchen Li, Haijie Ma, Yanping Xu, Lei Lv   +8 more
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Abnormal Cystic Tumor in a Patient with Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome: Evidence of a Precursor Lesion?

Case Reports in Urology, 2015
The hereditary leiomyomatosis and renal cell cancer (HLRCC) association is a rare syndrome caused by mutation of the Kreb’s cycle enzyme, fumarate hydratase (FH). It is characterized by unusually aggressive type 2 papillary renal cell histology.
Benjamin T. Ristau, Sonal N. Kamat, Tatum V. Tarin   +2 more
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Fumarate Hydratase Restrains mtDNA Attenuates LPS-Induced Acute Lung Injury Through cGAS-STING Pathways

Journal of Inflammation Research
Zewen Jiang,1,* Ruyuan He,2,* Yujian Zhong,1,* Bohao Liu,3 Ziqi He4 1Department of Orthopedic Surgery, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Department of Thoracic Surgery, Renmin Hospital of Wuhan ...
Jiang Z, He R, Zhong Y, Liu B, He Z
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