Results 81 to 90 of about 291 (129)

Fumarate Hydratase-Deficient Renal Cell Carcinoma [PDF]

Mayo Clinic Proceedings, 2020
Sounak, Gupta, Lori A, Erickson
openaire   +2 more sources

Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis

The Journal of Clinical Investigation
The inflammatory response resulting from the abnormal accumulation of metabolites has been implicated in the pathogenesis of organ fibrosis; however, its role and underlying mechanisms in renal fibrosis remain unclear.
Shuai Sun, Xu-yang Yan, Yu-hang Dong, Jian-min You, Zhen-yu Guo, Dong-xue Lv, Shuai-shuai Xie, Rui Hou, Xiang-yu Li, Ju-tao Yu, Xiao-yu Shen, Jie Wei, Zhen-yu Song, Zi-qi Chen, Yun-long Zhu, Xing-xin Xu, Juan Jin, Jia-gen Wen, Hao Wang, Xiao-ming Meng, Wei Wang   +20 more
doaj   +1 more source

Fumarate Hydratase-Deficient Leiomyomas: A Retrospective Case Series with Clinical and Familial Findings Suggestive of Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome

Gynecology Obstetrics & Reproductive Medicine
OBJECTIVES: Fumarate hydratase (FH)-deficient uterine leiomyomas are a rare variant of smooth muscle tumors that may signal underlying hereditary syndromes like HLRCC, making their recognition crucial for gynecologists and pathologists.
Tural Ismayilov, Suleyman Cemil Oglak, Nebahat Uzunay, Zeynep Yavas Yucel   +3 more
doaj   +1 more source

Fumarate Hydratase, Mitochondrial [PDF]

, 2020
openaire   +1 more source

Specificity of Fumarate Hydratase

Journal of Biological Chemistry, 1968
S Nakamura, H Ogata
openaire   +1 more source

Fumarate hydratase in cancer research: scientific trends and findings over 22 years

Discover Oncology
Objective Fumarate hydratase (FH) is a key enzyme in the Krebs cycle and cellular energy metabolism, playing a crucial role in tumorigenesis. It is considered a prognostic, diagnostic, and therapeutic target for many types of cancer.
Cem Yalaza, Serife Efsun Antmen
doaj   +1 more source

A Case of Recurrent Multiple Uterine Fibroids Associated with Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC): Insights into Fumarate Hydratase (FH) Deficiency

International Journal of Women's Health
Wan Li, Shu Bao, Jie Duan Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, Province, People’s Republic of ChinaCorrespondence: Jie Duan, Department of Gynecology, Maternal and Child Health Hospital of Hubei ...
Li W, Bao S, Duan J
doaj  

Léiomyome fumarate hydratase-déficient

Forum Médical Suisse ‒ Swiss Medical Forum
Catherine Connolly, Barbara Padberg Sgier   +1 more
openaire   +1 more source

Specificity of fumarate hydratase. I. Formation of oxalacetate from unnatural (--)-tartrate by fumarate hydratase.

The Journal of biological chemistry, 1968
S, Nakamura, H, Ogata
openaire   +1 more source

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Fumarate hydratase as a therapeutic target in renal cancer

Expert Opinion on Therapeutic Targets, 2020
Renal cell carcinoma (RCC) is a heterogeneous group of cancers that can occur sporadically or as a manifestation of various inherited syndromes. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is one such inherited syndrome that predisposes patients to HLRCC-associated RCC.
Mehdi Mollapour, Gennady Bratslavsky, Michael Daneshvar   +2 more
exaly   +3 more sources