Results 61 to 70 of about 291 (129)

Clinical characteristics and follow‐up of 77 patients with pathogenic fumarate hydratase variants

BJU International, Volume 138, Issue 3, Page 397-399, September 2026.
Matthijs Duijn, Aline M. Tijans, R. Jeroen A. van Moorselaar, Marjoleine F. Broekema, Marleen E. de Lange, Emiel D. Post Uiterweer, Marilyne M. Lange, Naomi Donner, Markus V. Starink, Antoinette Hollestelle, Liselotte P. van Hest, Femke Struik, Patricia J. Zondervan   +12 more
wiley   +1 more source

Metabolic design considerations for recycling of respiratory CO2 in leaves

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY Net carbon gain in plants is significantly reduced by the loss of assimilated carbon due to respiration and other metabolism in heterotrophic tissues. Avoiding this loss is difficult due to the essential nature of the metabolic processes involved but it could be possible to engineer metabolism to reuse the generated CO2.
Corinna Hartinger, Edward N. Smith, Lee J. Sweetlove   +2 more
wiley   +1 more source

Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues

Nature Communications
Aberrantly accumulated metabolites elicit intra- and inter-cellular pro-oncogenic cascades, yet current measurement methods require sample perturbation/disruption and lack spatio-temporal resolution, limiting our ability to fully characterize their ...
Marlous Kamp, Jakub Surmacki, Marc Segarra Mondejar, Tim Young, Karolina Chrabaszcz, Fadwa Joud, Vincent Zecchini, Alyson Speed, Christian Frezza, Sarah E. Bohndiek   +9 more
doaj   +1 more source

Fumarate and fumarate hydratase: an immunometabolite regulator of inflammation and diseases

Frontiers in Immunology
Once regarded solely as an intermediate of the tricarboxylic acid (TCA) cycle involved in energy production, fumarate has now emerged as a pivotal immunometabolite with far-reaching effects on inflammatory signaling and immune cell fate.
Zewen Jiang, Yujian Zhong, Zhuokun He, Ziqi He, Wei Wang, Ruyuan He   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Fumarate hydratase-deficient uterine leiomyoma: A rare case report and literature review

Frontiers in Oncology
BackgroundUterine leiomyoma is the most common benign tumor in the female reproductive system. Fumarate hydratase (FH)-deficient leiomyoma is a rare subtype characterized by distinctive histopathological and immunophenotypic features and may be ...
Qiang Wang, Yanqing Li, Yanshe Shao, Ying Chen, Hui Ren, Xia Ji, Jinying Fu   +6 more
doaj   +1 more source

Reporting on FH-deficient renal cell carcinoma using circulating succinylated metabolites

The Journal of Clinical Investigation, 2023
Fumarate hydratase–deficient (FH-deficient) renal cell carcinoma (RCC) represents a particularly aggressive form of kidney cancer. FH-deficient RCC arises in the setting of germline, or solely somatic, mutations in the FH gene, a two-hit tumor suppressor
Divya Bezwada, James Brugarolas
doaj   +1 more source

SGO1 and SGO2 are Associated With Disease Progression and an Immunosuppressive Microenvironment in Papillary Renal Cell Carcinoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Shugoshin proteins SGO1 and SGO2 regulate chromosome cohesion and segregation during mitosis and meiosis, and their aberrant expression is implicated in several cancers. However, the mechanistic involvement of these two proteins in papillary renal cell carcinoma (KIRP) and their contribution to immune evasion remains unclear ...
Han Fu, Alisherjon Ibrohimov, Hao Zheng, Yue Pan, Jieyu Hu, Banzhan Ruan, Hang Huang, Shi Li   +7 more
wiley   +1 more source

Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source

npj Systems Biology and Applications
Genome-scale metabolic models (GSMM) are commonly used to identify gene deletion sets that result in growth coupling and pairing product formation with substrate utilization and can improve strain performance beyond levels typically accessible using ...
Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay   +7 more
doaj   +1 more source

Reed's syndrome

Indian Journal of Dermatology, 2018
Multiple cutaneous and uterine leiomyomatosis (MCUL), also known as Reed's syndrome, is a rare genodermatosis, with an autosomal dominant pattern of inheritance.
Filipa Tavares Almeida, Rui P Santos, Sofia D Carvalho, Maria C Brito   +3 more
doaj   +1 more source