Results 121 to 130 of about 3,274 (204)

Characterisation of the Self‐Sufficient Cytochrome P450 CYP116B234 From Rhodococcus globerulus and Its Suggested Native Role in 2‐Hydroxyphenylacetic Acid Metabolism

Microbial Biotechnology, Volume 18, Issue 3, March 2025.
A self‐sufficient P450 gene (CYP116B234) was identified from Rhodococcus globerulus, a soil‐dwelling bacterium isolated from beneath an Eucalypt tree. CYP116B234 consists of heme and reductase domains fused in a single polypeptide. Proteomic analysis suggested the role of CYP116B234 may be to initiate 2‐hydroxyphenylacetic acid catabolism as part of ...
Simran Kundral, Hannah Beamish, Peter D. Giang, Lauren J. Salisbury, Amanda S. Nouwens, Sunil K. Khare, Paul V. Bernhardt, Jeffrey R. Harmer, Stephen G. Bell, James J. De Voss   +9 more
wiley   +1 more source

Fluorescent nanoparticles for sensing

, 2020
Nanoparticle-based fluorescent sensors have emerged as a competitive alternative to small molecule sensors, due to their excellent fluorescence-based sensing capabilities.
Acosta, Alarcón-Angeles, Albertazzi, Aldewachi, Ali, Ali, Alivisatos, Amelia, Amin, Arai, Arcudi, Bae, Bagwe, Behnke, Berti, Bhattacharyya, Biteen, Bruchez, Byrappa, Cai, Cao, Carregal-Romero, Chai, Chandra, Chen, Chen, Chen, Chen, Chen, Chen, Choi, Chu, Colom, De Luca, del Mercato, del Mercato, Derr, Dhenadhayalan, Diaz-Diestra, Ding, Dmitriev, Dong, Duong, Duong, Enkin, Fehérvári, Fernández-Argüelles, Fong, Fu, Furukawa, Gao, Govindaraju, Guo, Ha, Halter, Herschel, Hines, Hornig, Hou, Hu, Huang, Huang, Huang, Iyer, Jelinek, Jeong, Jiang, Jimenez de Aberasturi, Jin, Kim, Kircher, Kong, Lakowicz, Lan, Lee, Lemon, Leobandung, Leonhardt, Lepore, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Liu, Liu, Liu, López-Duarte, Ma, Ma, Medintz, Melnychuk, Miao, Monteiro, Naccarato, Nandi, Ng, Nie, Nooney, Ou, Pan, Pellegrino, Peng, Pompa, Potter, Qian, Qian, Qu, Rakovich, Rao, Reisch, Riccò, Riedinger, Ruedas-Rama, Saha, Samokhvalov, See, Shamirian, Shang, Shang, Shangguan, Shao, Shen, SMITH, Song, Stich, Stryer, Stöber, Su, Sun, Tang, Thiyagarajan, Toh, Ukeda, Valeur, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wen, Widengren, Wolfbeis, Wu, Wu, Wu, Wu, Wu, Xie, Xie, Xu, Xu, Yang, Yang, Ye, Yin, Yin, Yu, Yu, Yu, Zadran, Zeng, Zhang, Zhang, Zhang, Zhao, Zheng, Zhu, Zor, Zorman   +183 more
core   +1 more source

Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways [PDF]

, 2013
Parasitic roundworm infections plague more than 2 billion people (1/3 of humanity) and cause drastic losses in crops and livestock. New anthelmintic drugs are urgently needed as new drug resistance and environmental concerns arise. A "chokepoint reaction"
Abubucker, Sahar, Huang, Stanley Ching-Cheng, Mitreva, Makedonka, Pearce, Edward J, Powell, Kerrie, Rosa, Bruce A, Schedl, Tim, Taylor, Christina M, Wang, Qi   +8 more
core   +4 more sources

Determination of sulfhydryl groups and disulfide linkages of fumarylacetoacetate fumaryl hydrolase.

, 1978
Dept. of Chemistry and Biochemistry. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1978 .C456. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1978.
Behling Cheng
openalex   +4 more sources

Extensive double humanization of both liver and hematopoiesis in FRGN mice

Stem Cell Research, 2014
Preclinical research in animals often fails to adequately predict the outcomes observed in human patients. Chimeric animals bearing individual human tissues have been developed to provide improved models of human-specific cellular processes.
Elizabeth M. Wilson, J. Bial, Branden Tarlow, G. Bial, B. Jensen, D.L. Greiner, M.A. Brehm, M. Grompe   +7 more
doaj   +1 more source

FAHD1-mediated pyruvate metabolism in hepatocellular carcinoma: Multi-omics and causal genetic evidence

HGG Advances
Summary: Hepatocellular carcinoma (HCC) progression is driven by metabolic reprogramming in the tumor microenvironment (TME), yet the causal regulators of pyruvate metabolism and their spatial interplay remain elusive.
Jin Huang, Shijie Liang, Jiamin Sun, Huaping Chen   +3 more
doaj   +1 more source

Successive Drug Therapy for a Very Rare Autosomal Diseases [PDF]

, 2019
It is very rare to find reports concerning a drug therapy successively treating chromosomal abnormalities. In this paper, we are reporting a successive use of nitisinone in treating a fatal and very rare autosomal disease called hereditary tyrosinemia ...
Al-Noaemi, Mohammed Chyad, Daghriri, Hassan Ali   +1 more
core   +2 more sources

Implementation of a Methodology for the Detection of Biochemical Markers in Type 1 Tyrosinemia

Revista Finlay, 2023
Foundation: hereditary tyrosinemia type I or hepato-renal tyrosinemia is an autosomal recessive disease caused by deficiency of the enzyme fumarylacetoacetate hydrolase. Due to its metabolic complexity, its confirmation requires a set of highly expensive
Iovana Fuentes Cortés, Beliany Pacheco Suárez, Dulce María Charón Savón   +2 more
doaj  

Pharmaceutical Crops: An Overview [PDF]

, 2010
Pharmaceutical crops is an ambiguous term used by biologists and chemists for different categories of plants. We define pharmaceutical crops as those cultivated species that are used for extraction or preparation of therapeutic substances such as active ...
Antoun, Mikhail, Balick, Michael, Cragg, Gordon, Li, Shiyou, Yang, Peiying, Yuan, Wei   +5 more
core   +1 more source

Evolution of tyrosinemia type 1 disease in patients treated with nitisinone in Spain [PDF]

, 2019
Nephrocalcinosis; Phenotype; Severe liver dysfunctionNefrocalcinosis; Fenotipo; Disfunción hepática graveNefrocalcinosi; Fenotip; Disfunció hepàtica greuTreatment with nitisinone (NTBC) has brought about a drastic improvement in the treatment and ...
Aldámiz-Echevarría, Luís, Couce, María Luz, Martín-Hernández, Elena, Navas, Victor, Pintos Morell, Guillem, Sánchez-Pintos, Paula, Vitoria, Isidro   +6 more
core   +1 more source