Results 1 to 10 of about 5,465,657 (269)

Ultrasound therapy for a week promotes regeneration and reduces pro-inflammatory macrophages in a rat sciatic nerve autograft model

Scientific Reports, 2023
Peripheral nerve injury causes long-term motor dysfunction. Ultrasound (US) therapy is expected to accelerate peripheral nerve regeneration. However, its optimal usage and effects on macrophage phenotypes during peripheral nerve regeneration remain ...
Hideki Kawai, Akira Ito, Asuka Kawaguchi, Momoko Nagai-Tanima, Ryo Nakahara, Shixuan Xu, Hiroshi Kuroki   +6 more
doaj   +1 more source

Analysis of docosahexaenoic acid hydroperoxide isomers in mackerel using liquid chromatography–mass spectrometry

Scientific Reports, 2023
Docosahexaenoic acid (DHA) is mostly esterified in food and is easily oxidized by exposure to heat or light. Hydroperoxide positions of DHA mono-hydroperoxide (DHA;OOH) provide information on oxidation mechanisms (e.g., radical- or singlet oxygen ...
Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa   +2 more
doaj   +1 more source

Elucidation of Olive Oil Oxidation Mechanisms by Analysis of Triacylglycerol Hydroperoxide Isomers Using LC-MS/MS

Molecules, 2022
Despite the importance of the insight about the oxidation mechanisms (i.e., radical and singlet oxygen (1O2) oxidation) in extra virgin olive oil (EVOO), the elucidation has been difficult due to its various triacylglycerol molecular species and complex ...
Hayato Takahashi, Shunji Kato, Naoki Shimizu, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Jun Imagi, Kiyotaka Nakagawa   +8 more
doaj   +1 more source

Carboxylic acids derived from triacylglycerols that contribute to the increase in acid value during the thermal oxidation of oils

Scientific Reports, 2022
Acid value (AV), is a widely used indicator of oil degradation that, by definition, measures the free fatty acids formed via the hydrolysis of triacyclglycerols.
Masayoshi Sakaino, Takashi Sano, Shunji Kato, Naoki Shimizu, Junya Ito, Halida Rahmania, Jun Imagi, Kiyotaka Nakagawa   +7 more
doaj   +1 more source

One session of 20 ​N cyclic compression induces chronic knee osteoarthritis in rats: A long-term study

Osteoarthritis and Cartilage Open, 2022
Objective: Mechanical stimulation is a risk factor for knee osteoarthritis. Non-surgical compression has been used to study the effects of mechanical stimulation in vivo.
Zixi Zhao, Akira Ito, Akihiro Nakahata, Xiang Ji, Chia Tai, Motoo Saito, Kohei Nishitani, Tomoki Aoyama, Hiroshi Kuroki   +8 more
doaj   +1 more source

The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin

Scientific Reports, 2023
Vitamin E is classified into tocopherol (Toc) and tocotrienol (T3) based on its side chains. T3 generally has higher cellular uptake than Toc, though the responsible mechanism remains unclear. To elucidate this mechanism, we hypothesized and investigated
Takashi Nakatomi, Mayuko Itaya-Takahashi, Yosuke Horikoshi, Naoki Shimizu, Isabella Supardi Parida, Mirinthorn Jutanom, Takahiro Eitsuka, Yoshikazu Tanaka, Jean-Marc Zingg, Tatsuya Matsura, Kiyotaka Nakagawa   +10 more
doaj   +1 more source

L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy

Frontiers in Pharmacology, 2023
Lenvatinib is an oral tyrosine kinase inhibitor that acts on multiple receptors involved in angiogenesis. Lenvatinib is a standard agent for the treatment of several types of advanced cancers; however, it frequently causes muscle-related adverse ...
Zheng Jing, Tomohiro Iba, Tomohiro Iba, Hisamichi Naito, Pingping Xu, Jun-ichi Morishige, Naoto Nagata, Hironao Okubo, Hitoshi Ando   +8 more
doaj   +1 more source

Improving water dispersibility and bioavailability of luteolin using microemulsion system

Scientific Reports, 2022
We have studied the physiological effects and health functions of luteolin, especially focusing on its absorption and metabolism. Recent studies have reported the advantages of microemulsion to improve the bioavailability of poorly water-soluble ...
Ayaka Miyashita, Junya Ito, Isabella Supardi Parida, Naoki Syoji, Tomoyuki Fujii, Hidehiro Takahashi, Kiyotaka Nakagawa   +6 more
doaj   +1 more source

Edoxaban Dosing Time Affects Blood Coagulation Inhibition in Rats

TH Open, 2021
Coagulation–fibrinolytic system activity shows daily rhythmicity, with hypercoagulability in the morning and hypocoagulability in the evening. Consequently, the efficacy of anticoagulants may be influenced by their dosing time.
Naoto Nagata, Muneo Kawasumi, Akio Fujimura, Hitoshi Ando   +3 more
doaj   +1 more source

Chronic Treatment with Metformin Has No Disrupting Effect on the Hepatic Circadian Clock in Mice

Medicina, 2022
Background and Objectives: The antidiabetic agent metformin is known to activate AMP-activated protein kinase (AMPK) in various tissues. Because AMPK can modulate intracellular circadian clocks through regulating the stability of clock components, a ...
Nazmul Hasan, Koki Sugimoto, Koki Yamada, Jun-ichi Morishige, Kentaro Ushijima, Akio Fujimura, Naoto Nagata, Hitoshi Ando   +7 more
doaj   +1 more source