Results 121 to 130 of about 14,444,288 (391)

Loss of testosterone impairs anti-tumor neutrophil function. [PDF]

, 2020
In men, the incidence of melanoma rises rapidly after age 50, and nearly two thirds of melanoma deaths are male. The immune system is known to play a key role in controlling the growth and spread of malignancies, but whether age- and sex-dependent ...
Arditi, Moshe, Crother, Timothy R, Lane, Malcolm E, Luu, Michael, Markman, Janet L, Martinon, Daisy, Noval Rivas, Magali, Porritt, Rebecca A, Posadas, Edwin M, Wakita, Daiko   +9 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Glia as architects of central nervous system formation and function

Science, 2018
Glia constitute roughly half of the cells of the central nervous system (CNS) but were long-considered to be static bystanders to its formation and function.
N. J. Allen, D. Lyons
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

The Fungal Cell Wall: Structure, Biosynthesis, and Function

Microbiology spectrum, 2017
The molecular composition of the cell wall is critical for the biology and ecology of each fungal species. Fungal walls are composed of matrix components that are embedded and linked to scaffolds of fibrous load-bearing polysaccharides. Most of the major
N. Gow, J. Latgé, C. Munro
semanticscholar   +1 more source

Metal-polyphenol-network coated R612F nanoparticles reduce drug resistance in hepatocellular carcinoma by inhibiting stress granules

Cell Death Discovery
Stress granules (SGs) are considered to be the nonmembrane discrete assemblies present in the cytoplasm to cope with various environmental stress. SGs can promote the progression and drug resistance of hepatocellular carcinoma (HCC).
Yue Zhou, Tongjia Zhang, Shujie Wang, Zitao Jiao, Kejia Lu, Xinyi Liu, Hui Li, Wei Jiang, Xiaowei Zhang   +8 more
doaj   +1 more source

Chemical genetics and strigolactone perception [version 1; referees: 2 approved]

F1000Research, 2017
Strigolactones (SLs) are a collection of related small molecules that act as hormones in plant growth and development. Intriguingly, SLs also act as ecological communicators between plants and mycorrhizal fungi and between host plants and a collection of
Shelley Lumba, Michael Bunsick, Peter McCourt   +2 more
doaj   +1 more source

Bettering Humanity through Biology [PDF]

, 2018
Biology is arguably referred to as the “science of the XXIth century”. This prestigious title intrinsically contains a huge responsibility. For many centuries, Biology has contributed directly or indirectly to bettering humankind, although its obvious ...
Mota, Manuel
core  

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Human nature and institutional analysis [PDF]

This essay reviews some findings in cognition sciences and examines their consequences for the analysis of institutions. It starts by exploring how humans’ specialization in producing knowledge ensures our success in dominating the environment but also ...
Benito Arruñada
core