Results 151 to 160 of about 14,444,288 (391)
Effects of mechanical ventilation on diaphragm function and biology [PDF]
Ghislaine Gayan‐Ramirez, Marc Decramer
openalex +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää+2 more
wiley +1 more source
Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins
Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling.
Lin Li, Jie Ran
doaj +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos+3 more
wiley +1 more source
Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus (DENV). The replication of DENV relies on the processing of its genome-encoded polyprotein by both viral protease NS3 (NS3pro) and host proteases.
Sen Ma+9 more
doaj +1 more source
Some Misconceptions on Cell Structure and Function Held by \'A\' Level Biology Students\' Implications for Curriculum Development [PDF]
EMZ Tambo, J. P. Mukaro, J Mahaso
openalex +1 more source
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
Anna S. Monzel, J. Enríquez, M. Picard
semanticscholar +1 more source