Longevity of System Functions in Biology and Biomimetics: A Matter of Robustness and Resilience [PDF]
, 2023 Max D. Mylo, Olga Speck
openalex +1 more source
10 Years of GWAS Discovery: Biology, Function, and Translation.
American Journal of Human Genetics, 2017 P. Visscher +6 more
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins
Cell Death and DiseaseCilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling.
Lin Li, Jie Ran
doaj +1 more source
Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022 [PDF]
, 2023 Mette M. Rosenkilde, Signe Mathiasen
openalex +1 more source
Functionalized Protein Binders in Developmental Biology
Annual Review of Cell and Developmental BiologyDevelopmental biology has greatly profited from genetic and reverse genetic approaches to indirectly studying protein function. More recently, nanobodies and other protein binders derived from different synthetic scaffolds have been used to directly dissect protein function.
Sophie T, Schnider +3 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins
mSystemsDengue fever is a mosquito-borne tropical disease caused by the dengue virus (DENV). The replication of DENV relies on the processing of its genome-encoded polyprotein by both viral protease NS3 (NS3pro) and host proteases.
Sen Ma +9 more
doaj +1 more source
Novel Chemical Biology Methods Illuminate the Function of Single G Protein-Coupled Receptors [PDF]
, 2015 Thomas Huber, Thomas P. Sakmar
openalex +1 more source
Role of transforming growth factor Beta in corneal function, biology and pathology.
Current molecular medicine, 2010 A. Tandon +4 more
semanticscholar +1 more source