Results 231 to 240 of about 14,444,288 (391)
SYSCILIA, “A systems biology approach to dissect cilia function and its disruption in human genetic disease” [PDF]
Ronald Roepman+17 more
openalex +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Relating sparse and predictive coding to divisive normalization. [PDF]
Lian Y, Burkitt AN.
europepmc +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Meeting Report on the Symposium Organized to Celebrate the 40th Anniversary of the French Society for Cell Biology. [PDF]
Niedergang F, Chabrier R, Tardieux I.
europepmc +1 more source
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen+12 more
wiley +1 more source
Author Correction: Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids. [PDF]
Podgorski JM+8 more
europepmc +1 more source