Results 251 to 260 of about 3,596,843 (342)

Structural and immunological impacts of TOLLIP nsSNPs: A computational biology approach to drug discovery and immune system modulation. [PDF]

PLoS One
Habib O, Ishaq S, Habib K, Khattak A, Yang W, Li Z, Bukhari K, Ullah A, Ahmad A, Ali Q.   +9 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LDBT instead of DBTL: combining machine learning and rapid cell-free testing. [PDF]

Nat Commun
Clark-ElSayed A, Harrison IM, Olsen ML, Lazar JT, Jewett MC, Ellington AD.   +5 more
europepmc   +1 more source

The diverse functions of Krüppel‐like factors 4 and 5 in epithelial biology and pathobiology

, 2007
Beth B. McConnell, Amr M. Ghaleb, Mandayam O. Nandan, Vincent W. Yang   +3 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Optimal harvesting of a continuously age-structured population with density dependence. [PDF]

PLoS One
Opmeer M.
europepmc   +1 more source

Microproteins in Metabolic Biology: Emerging Functions and Potential Roles as Nutrient-Linked Biomarkers [PDF]

Seong‐Hee Ko, Belong Cho, Dayeon Shin
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ZMIZ1 and estrogen receptor α form an essential partnership in endometrial biology. [PDF]

J Clin Invest
Rahman MS, So KA, Jeong JW.
europepmc   +1 more source

3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function (Adv. Biology 4/2025) [PDF]

GaYoung Park, Josh A. Grey, Foteini Mourkioti, Woojin M. Han   +3 more
openalex   +1 more source