Results 251 to 260 of about 3,539,296 (346)

The Immunoglobulin Domain of SISS-1/EGF is Required for its Function. [PDF]

MicroPubl Biol
Jones JG, Van Buskirk C.
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Correction to: Differential Effects of Prenylation and S-Acylation on Type I and II ROPS Membrane Interaction and Function. [PDF]

Plant Physiol
europepmc   +1 more source

A study of RNA splicing and protein expression in the living human brain. [PDF]

PLoS One
Kopell BH, Kaji DA, Liharska LE, Vornholt E, Lund A, Hashemi A, Thompson RC, Johnson JS, Bussola N, Cheng E, Park YJ, Shah P, Ma W, Searfoss R, Miller GM, Chand NM, Humphrey J, Wilkins L, Ziafat K, Silk H, Linares LM, Sullivan B, Feng C, Cohen V, Kota P, Moya E, Rieder MK, Nadkarni GN, Breen MS, Scarpa J, Narain NR, Wang P, Kiebish MA, Schadt EE, Beckmann ND, Charney AW.   +35 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Editorial: Exploring lymphocyte signaling: from health to disease. [PDF]

Front Immunol
Molfetta R, Simeoni L.
europepmc   +1 more source

Understanding high-density lipoprotein function in disease: Recent advances in proteomics unravel the complexity of its composition and biology

, 2014
Ruth Birner‐Gruenberger, Matthias Schittmayer, Michael Holzer, Gunther Marsche   +3 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

The role of structural connectivity on brain function through a Markov model of signal transmission. [PDF]

PLoS One
Razban RM, Banerjee A, Mujica-Parodi LR, Bahar I.   +3 more
europepmc   +1 more source

Contrasting Functions of Notch Signaling In Normal and Pathogenic Adrenal Biology. [PDF]

, 2012
Derek P. Simon
openalex