Results 251 to 260 of about 14,444,288 (391)

Chemical Biology Strategies for Posttranslational Control of Protein Function [PDF]

, 2014
Rishi Rakhit, Raul Navarro, Thomas J. Wandless   +2 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Structural Changes in Gene Ontology Reveal Modular and Complex Representations of Biological Function. [PDF]

Mol Biol Evol
Valverde S, Vidiella B, Martínez-Redondo GI, Duran-Nebreda S, Fernández R, Bombarely A, Rojas AM, Bentley RA.   +7 more
europepmc   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Impact of Herbicides on Soil Biology and Function

, 2016
M. Rose, T. Cavagnaro, C. Scanlan, Terry J. Rose, T. Vancov, S. Kimber, I. Kennedy, R. Kookana, L. Zwieten   +8 more
semanticscholar   +1 more source

Model-free photon analysis of diffusion-based single-molecule FRET experiments. [PDF]

Nat Commun
Terterov I, Nettels D, Lastiza-Male T, Bartels K, Löw C, Vancraenenbroeck R, Carmel I, Rosenblum G, Hofmann H.   +8 more
europepmc   +1 more source

Implementation of a Project-Based Molecular Biology Laboratory Emphasizing Protein Structure–Function Relationships in a Large Introductory Biology Laboratory Course

, 2011
Daniel J. Treacy, Saumya M. Sankaran, Susannah Gordon-Messer, Danielle L. Saly, Rebecca Miller, R. Stefan Isaac, Melissa S. Kosinski‐Collins   +6 more
openalex   +1 more source

Distinguishing between "Function" and "Effect" in Genome Biology [PDF]

, 2014
W. Ford Doolittle, T. D. P. Brunet, Stefan Linquist, T. Ryan Gregory   +3 more
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Editorial: The role of enhancers in cancer. [PDF]

Front Cell Dev Biol
Forcales SV.
europepmc   +1 more source