Results 281 to 290 of about 3,539,296 (346)

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Forest soundscapes improve mood, restoration and cognition, but not physiological stress or immunity, relative to industrial soundscapes. [PDF]

Sci Rep
Longman DP, Van Hedger SC, McEwan K, Griffin E, Hannon C, Harvey I, Kikuta T, Nickels M, O'Donnell E, Pham VA, Robinson J, Slater R, Szazvai M, Williams J, Shaw CN.   +14 more
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

CryoEMNet driven symmetry-aware molecular reconstruction through deep learning enhanced electron microscopy. [PDF]

Sci Rep
Arora S, Pan SH, Kumar S, Singh SK, Chauhan U, Alhalabi W, Arya V, Alsulami BS, Hsu CH, Chui KT, Gupta BB.   +10 more
europepmc   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Exploring transcriptome plasticity at the intersection of cell signaling, metabolism and computational biology. [PDF]

Exp Mol Med
Yong J.
europepmc   +1 more source

IonBench: A benchmark of optimisation strategies for mathematical models of ion channel currents. [PDF]

PLoS Comput Biol
Owen MJ, Mirams GR.
europepmc   +1 more source

Long-term functional rescue of trauma-induced vision loss by a novel, small molecule TrkB modulator. [PDF]

PLoS One
Modgil S, Walker CL, Chrenek MA, Grossniklaus HE, McDonald FE, Iuvone PM.   +5 more
europepmc   +1 more source