Results 321 to 330 of about 14,894,566 (393)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Reframing the significance of menstruation: evolutionary insights from an organismal-relational perspective. [PDF]
Etxeberria A, Rodriguez-Muguruza A.
europepmc +1 more source
A methodology for calculating the rarity of diverse proteins based on functional specificity and thermodynamic stability. [PDF]
Miller BJ.
europepmc +1 more source
FUNCTION IN BIOLOGY: ETIOLOGICAL AND ORGANIZATIONAL PERSPECTIVES
Charbel Niño El-Hani, Nei Nunes-Neto
openalex +1 more source
Novel artificial selection method improves function of simulated microbial communities. [PDF]
Vessman B +3 more
europepmc +1 more source
Autophagy, Cellular Senescence and Oxidative Stress in Ageing and Age-Related Diseases. [PDF]
Trachana V.
europepmc +1 more source

