Results 51 to 60 of about 6,362,947 (287)

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Overcoming mental blocks : a blocks-based approach to Experience Sampling studies [PDF]

, 2017
Experience Sampling Method (ESM) studies repeatedly survey participants on their behaviours and experiences as they go about their everyday lives. Smartphones afford an ideal platform for ESM study applications as devices seldom leave their users, and ...
Quigley, Aaron John, Rough, Daniel; id_orcid, Aaron Quigley, Quigley, Aaron, Rough, Daniel John, Daniel Rough   +5 more
core   +1 more source

Exact WKB analysis of ℂℙ1 holomorphic blocks

Journal of High Energy Physics, 2019
We study holomorphic blocks in the three dimensional N $$ \mathcal{N} $$ = 2 gauge theory that describes the ℂℙ1 model. We apply exact WKB methods to analyze the line operator identities associated to the holomorphic blocks and derive the analytic ...
Sujay K. Ashok, P. N. Bala Subramanian, Aditya Bawane, Dharmesh Jain, Dileep P. Jatkar, Arkajyoti Manna   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

TAPping into mental models with blocks [PDF]

, 2017
Trigger-Action Programming (TAP) has been shown to support end-users' rule-based mental models of context-aware applications. However, when desired behaviours increase in complexity, this can lead to ambiguity that confuses events, states, and how they ...
Quigley, A., Rough, Daniel; id_orcid, Aaron Quigley, Quigley, Aaron, Daniel Rough, Rough, D.   +5 more
core   +1 more source

5D AGT conjecture for circular quivers

Physics Letters B
The best way to represent generic conformal blocks is provided by the free-field formalism, where they acquire a form of multiple Dotsenko-Fateev-like integrals of the screening operators.
A. Mironov, A. Morozov, Sh. Shakirov
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source