Results 71 to 80 of about 7,650,207 (262)

STAT3 signaling pathway plays importantly genetic and functional roles in HCV infection

open access: yesMolecular Genetics & Genomic Medicine, 2019
Background Hepatitis C virus (HCV) infection is an extensive health problem, which leads to serious liver diseases. Host genetic polymorphisms were associated with HCV infection, progression, and treatment effect of patients.
Yuzhu Song   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Functional genomics of Arabidopsis TULP proteins

open access: yes, 2014
[[sponsorship]]植物暨微生物學研究所[[note]]已出版;有審查制度 ...
J. F. Shaw, Shaw, J. F.
core  

Design of Functional Foods using Synthetic Conjugates [PDF]

open access: yes, 2003
Nutrigenomics can provide a new development of research on functional food and we can create new effective functional foods using the nutrigenomical technique in the future.
Nakamura, K
core  

Amphibians and Reptiles Exhibit Different Ecological and Evolutionary Spatial Patterns in the Amazon Basin

open access: yesEcology and Evolution
Understanding spatial variability in ecological and evolutionary patterns is key to Amazonian biodiversity conservation. This study examined taxonomic, phylogenetic, and functional diversity across amphibians and reptiles, assessing the influence of ...
Jhon Jairo López‐Rojas   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Display of Functional Values for Debugging [PDF]

open access: yes, 2006
Functional values are used naturally in higher order functional programs, as they are commonly passed around or returned by other function. As such any debugger for these languages must be capable of conveying information about functional values to the ...
Davie, Thomas, Chitil, Olaf
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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