Results 61 to 70 of about 536,680 (248)

Eigenvector alignment: Assessing functional network changes in amnestic mild cognitive impairment and Alzheimer's disease.

PLoS ONE, 2020
Eigenvector alignment, introduced herein to investigate human brain functional networks, is adapted from methods developed to detect influential nodes and communities in networked systems.
Ruaridh A Clark, Niia Nikolova, William J McGeown, Malcolm Macdonald   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Checking the alignment of value-based business models and IT functionality [PDF]

Proceedings of the 2008 ACM symposium on Applied computing, 2008
Business{IT alignment is an ongoing activity of high importance for the success of a business. This is a hard task, especially in the context of value webs in which multiple businesses collaborate with each other to reach a common goal. Value models, as the outcome of the value web exploration phase, represent solutions for business people, but not for
Zarvic, Novica, Wieringa, Roel, van Eck, Pascal   +2 more
openaire   +3 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Lateral approach in robotic total knee arthroplasty for valgus knees: A step-by-step technique

SICOT-J
Total knee arthroplasty (TKA) in valgus knee deformities presents unique challenges, including alignment, soft tissue balance, and implant positioning. The lateral approach offers advantages over the traditional medial approach by improving direct access,
Andriollo Luca, Gregori Pietro, Koutserimpas Christos, Servien Elvire, Batailler Cécile, Kouyoumdjian Pascal, Lustig Sébastien   +6 more
doaj   +1 more source

Multi-view Autoencoder-based Functional Alignment of Multi-subject fMRI [PDF]

Jisuanji kexue
One of the major challenges in functional magnetic resonance imaging(fMRI) research is the heterogeneity of fMRI data across different subjects.On the one hand,analyzing multi-subject data is crucial for determining the generalizability and effectiveness
HUANG Shuo, SUN Liang, WANG Meiling, ZHANG Daoqiang
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Robotic total knee arthroplasty for moderate to high-grade valgus knee deformity: technique and outcomes

SICOT-J
Introduction: Although the surgical techniques and functional outcomes of conventional total knee arthroplasty (TKA) are well-established, there is limited data available on robotic arm-assisted TKA (RATKA) in the context of valgus knee arthroplasty. The
Kalyan Kanukuntla, Singh Ashish, Kumar Purushotam, Gundalli Akash Chandrashekar, Mane Sudhir Shankar, Swarnkar Himanshu, Singh Lavanya   +6 more
doaj   +1 more source