Patient‐Specific Functional Analysis: The Key to the Next Revolution Towards the Treatment of Hip and Knee Osteoarthritis [PDF]
, 2019 Janie L. Astephen Wilson +5 more
openalex +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Fold Bifurcation Theorem of Degenerate Solutions in a Perturbed Nonlinear Equation
Abstract and Applied Analysis, 2011 We consider a nonlinear equation F(ε,λ,u)=0, where the parameter ε is a perturbation parameter, F is a differentiable mapping from R×R×X to Y, and X, Y are Banach spaces.
Ping Liu, Yuwen Wang
doaj +1 more source
Functional Text Analysis of Oath for Engineers: Its Meta-functions and Linguistic Characteristics [PDF]
, 2019 This paper aims at investigating the language structure of the oath for engineers in the light of Systemic Functional Linguistics and examining how the oath is textualized to accomplish its roles and objectives as the guiding principle which sets the ...
Darmayanti, R. (Rita)
core
Diffusion Component Analysis: Unraveling Functional Topology in Biological Networks
, 2015 Complex biological systems have been successfully modeled by biochemical and genetic interaction networks, typically gathered from high-throughput (HTP) data. These networks can be used to infer functional relationships between genes or proteins.
Berger, Bonnie +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
PREDICTION OF DIPROPYL SULFONE PROPERTIES BY DENSITY FUNCTIONAL THEORY METHODS: CONFORMATIONAL ANALYSIS AND SIMULATED IR SPECTRUM [PDF]
, 2022 Zakar Kh. Papanyan, Liana S. Gabrielyan
openalex +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source