Results 71 to 80 of about 4,216,104 (317)

Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability [PDF]

, 2010
Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation.
Abecasis, G.R., de Jong, Arthur P. H., Timpson, Nicolas J., Heutink, Peter, Evans, D., Smit, A.B., Glaser, Beate, Evans, D.M., Verhage, Mathhijs, Lips, Esther S, Ruano, D., Heutink, P., Smit, A., Smith, D.G., Posthuma, Danielle, Lips, E., Abecasis, Goncalo R., Davey Smith, George, Evans, David M., Abecasis, G., Lips, E.S., Verhage, Matthijs, de Jong, A., Timpson, N., Cornelisse, L.N., Ruano, Dina, de Jong, A.P.H., Lips, Esther S., Verhage, M., Smith, George Davey, Jong, A.P.H. de, Smit, August B, Posthuma, D., Glaser, B., Timpson, Nicholas John, Cornelisse, L. Niels, Smit, August B., Davey Smith, G., Cornelisse, L Niels, Thimpson, N.J., Cornelisse, L., Evans, David M, de Jong, Arthur P.H., de Jong, Arthur P H, Abecasis, Gonçalo R, Posthuma, D.; id_orcid   +45 more
core   +1 more source

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters

Frontiers in Genetics, 2019
Given the central metabolic role of the liver, hepatic metabolites and transcripts reflect the organismal physiological state. Biochemical-clinical plasma biomarkers, hepatic metabolites, transcripts, and single nucleotide polymorphism (SNP) genotypes of
Siriluck Ponsuksili, Nares Trakooljul, Frieder Hadlich, Karen Methling, Michael Lalk, Eduard Murani, Klaus Wimmers, Klaus Wimmers   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Automatic detection of human gait events: a simple but versatile 3D algorithm

Journal of NeuroEngineering and Rehabilitation
Background Detecting Foot Strike and Foot Off events in human gait, which is cyclic yet variable, consistently requires expert correction. This subjective correction can reduce spatiotemporal parameters, joint kinematic and kinetic accuracy, regardless ...
Théo Vancanneyt, Camille Le Moal, Maxence Blard, Juliette Lenoir, Nicolas Roche, Céline Bonnyaud, Fabien Dubois   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Applications of functional analysis and operator theory

, 1980
Applications of functional analysis and operator theory.Print version record.Includes bibliographical references (pages 371-375) and index.Applications of functional analysis and operator theory ...
Hutson, V, Pym, J. S.(John Sydney),, Hutson, V., Pym, J S   +3 more
core  

nharoush/Functional-analysis-of-a-gene-locus: Data and Matlab code for figures and analyses

, 2023
These data and code are related to a Developmental Cell 2003 manuscript: "Functional analysis of a gene locus in response to non-canonical combinations of transcription factors".
nharoush
core   +1 more source

N-Acetylcysteine, N-Acetylcysteine Amide, and Thioredoxin Mimetic Peptides Regenerate Mercaptoalbumin and Exhibit Antioxidant Activity

Antioxidants
Albumin (HSA) is the most abundant circulating protein and plays a pivotal role in maintaining the redox state of the plasma. Three HSA proteoforms have been identified based on the redox state of cysteine 34.
Sonia Eligini, Marco Munno, Gloria Modafferi, Daphne Atlas, Cristina Banfi   +4 more
doaj   +1 more source

MethylToSNP: identifying SNPs in Illumina DNA methylation array data

Epigenetics & Chromatin, 2019
Background Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA.
Brenna A. LaBarre, Alexander Goncearenco, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Vanessa M. Hayes, Laura Elnitski   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source