Results 61 to 70 of about 8,080,966 (340)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

An integrated experimental and analytical approach for the analysis of the mechanical interaction between metal porous scaffolds and bone: implications for stress shielding in orthopedic implants

Frontiers in Bioengineering and Biotechnology
IntroductionMetal porous structures are becoming a standard design feature of orthopedic implants such as joint endoprostheses. The benefits of the pores are twofold: 1) help improve the cementless primary stabilization of the implant by increasing ...
Roberto Ramaglia Amadasi, Giulia Rogati, Erica Liverani, Alberto Leardini, Paolo Caravaggi   +4 more
doaj   +1 more source

Pomeron-Odderon Interactions: A Functional RG Flow Analysis

, 2016
In the quest for an effective field theory which could help to understand some non perturbative feature of the QCD in the Regge limit, we consider a Reggeon Field Theory (RFT) for both Pomeron and Odderon interactions and perform an analysys of the ...
Vacca, Gian Paolo
core   +1 more source

Global sensitivity analysis of computer models with functional inputs [PDF]

, 2007
Global sensitivity analysis is used to quantify the influence of uncertain input parameters on the response variability of a numerical model. The common quantitative methods are applicable to computer codes with scalar input variables. This paper aims to
Iooss, Bertrand, Ribatet, Mathieu
core   +6 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

ROI-Based Analysis of Functional Imaging Data [PDF]

, 2002
In this technical report, we present fMRI analysis techniques that test functional hypotheses at the region of interest (ROI) level. An SPM-compatible Matlab toolbox has been developed which allows the creation of subject-specific ROI masks based on ...
Ghosh, Satrajit, Guenther, Frank, Nieto-Castanon, Alfonso, Tourville, Jason   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters

Frontiers in Genetics, 2019
Given the central metabolic role of the liver, hepatic metabolites and transcripts reflect the organismal physiological state. Biochemical-clinical plasma biomarkers, hepatic metabolites, transcripts, and single nucleotide polymorphism (SNP) genotypes of
Siriluck Ponsuksili, Nares Trakooljul, Frieder Hadlich, Karen Methling, Michael Lalk, Eduard Murani, Klaus Wimmers, Klaus Wimmers   +7 more
doaj   +1 more source

MicroRNAs in blood act as biomarkers of colorectal cancer and indicate potential therapeutic targets

Molecular Oncology, 2021
Association studies have linked alterations of blood‐derived microRNAs (miRNAs) with colorectal cancer (CRC). Here, we performed a microarray‐based comparison of the profiles of 2549 miRNAs in 80 blood samples from healthy donors and patients with ...
Axel Stang, Hauke Weilert, Michael J. Lipp, Karl J. Oldhafer, Jörg D. Hoheisel, Chaoyang Zhang, Andrea S. Bauer   +6 more
doaj   +1 more source