Results 161 to 170 of about 33,941,795 (386)

Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma [PDF]

, 2021
Shumin Xie, Jin Li, Tuanfang Yin, Jihao Ren, Wei Liu   +4 more
openalex   +1 more source

Weak Symplectic Functional Analysis and General Spectral Flow Formula

, 2004
We consider a continuous curve of self-adjoint Fredholm extensions of a curve of closed symmetric operators with fixed minimal domain $D_m$ and fixed {\it intermediate} domain $D_W$.
Booss-Bavnbek, Bernhelm, Zhu, Chaofeng
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Static Bending and Vibration Analysis of a Rectangular Functionally Gradient Piezoelectric Plate on an Elastic Foundation [PDF]

, 2022
Wei Wang, Haonan Li, Linquan Yao
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Sign-changing solutions for coupled Schrödinger system

Boundary Value Problems
In this paper we study the following nonlinear Schrödinger system: { − Δ u + α u = | u | p − 1 u + 2 q + 1 λ | u | p − 3 2 u | v | q + 1 2 , x ∈ R 3 , − Δ v + β v = | v | q − 1 v + 2 p + 1 λ | u | p + 1 2 | v | q − 3 2 v , x ∈ R 3 , u ( x ) → 0 , v ( x )
Jing Zhang
doaj   +1 more source

Network analysis of functional brain connectivity in borderline personality disorder using resting-state fMRI

, 2016
Tingting Xu, Kathryn R. Cullen, Bryon A. Mueller, Mindy Westlund Schreiner, Kelvin O. Lim, S. Charles Schulz, Keshab K. Parhi   +6 more
openalex   +1 more source

Genomic identification and functional analysis of essential genes in Caenorhabditis elegans [PDF]

, 2018
Shicheng Yu, Chaoran Zheng, Fan Zhou, David L. Baillie, Ann M. Rose, Zixin Deng, Jeffrey Chu   +6 more
openalex   +1 more source

Enabling System Functionalities of Primary Care Practices for Team Dynamics in Transformation to Team-Based Care: A Qualitative Comparative Analysis (QCA) [PDF]

, 2023
Lingrui Liu, Alyna T. Chien, Sara J. Singer   +2 more
openalex   +1 more source