Results 291 to 300 of about 33,941,795 (386)

Functional analysis of a novel variant in the <i>COL5A1</i> gene in a Polish patient with the classical type of Ehlers-Danlos syndrome. [PDF]

Front Genet
Junkiert-Czarnecka A, Maciak K, Kacprzak MM, Łobodzińska A, Sobczyńska-Tomaszewska A, Jurkiewicz A, Gora M, Burzynska B, Pilarska-Deltow M, Haus O.   +9 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Compositional and Functional Analysis of Golden and Brown Flaxseed: Nutrients, Bioactive Phytochemicals, Antioxidant Activity, and Cellular Responses. [PDF]

Nutrients
Drozdowska M, Piasna-Słupecka E, Kmiecik K, Doskocil I, Lampova B, Smid P, Domagała B, Dziadek K.   +7 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Functional analysis of 6 variations in <i>FOXL2</i>. [PDF]

SAGE Open Med
Wang Y, Wu Q, Zhou Y, Liu W, Cao W, Fan Y, Li N.   +6 more
europepmc   +1 more source

Functional Data Analysis with R and MATLAB [PDF]

Adrian Bowman
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Peptide abundance correlations in metaproteomics enhance taxonomic and functional analysis of the human gut microbiome. [PDF]

NPJ Biofilms Microbiomes
Sun Z, Ning Z, Wu Q, Li L, Doxey AC, Figeys D.   +5 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Correction: Identification of the AKCDPK gene family and AkCDPK15 functional analysis under drought and salt stress. [PDF]

PLoS One
Gao P, Zou Y, Yang M, Li L, Qi Y, Guo J, Zhao Y, Liu J, Zhao J, Huang F, Yu L.   +10 more
europepmc   +1 more source