Results 41 to 50 of about 7,583,872 (228)
Sequence dependent UV damage of complete pools of oligonucleotides
Scientific Reports, 2023 Understanding the sequence-dependent DNA damage formation requires probing a complete pool of sequences over a wide dose range of the damage-causing exposure.
Corinna L. Kufner +8 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
An improved parser for data-oriented lexical-functional analysis [PDF]
, 2000 We present an LFG-DOP parser which uses fragments from LFG-annotated sentences to parse new sentences. Experiments with the Verbmobil and Homecentre corpora show that (1) Viterbi n best search performs about 100 times faster than Monte Carlo search while
Bod, Rens
core +3 more sources
N-Acetylcysteine Regenerates In Vivo Mercaptoalbumin
Antioxidants, 2022 Human serum albumin (HSA) represents the most abundant plasma protein, with relevant antioxidant activity due to the presence of the sulfhydryl group on cysteine at position 34 (Cys34), the latter being one of the major target sites for redox-dependent ...
Alessandra Anna Altomare +13 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Support vector machine for functional data classification [PDF]
, 2005 In many applications, input data are sampled functions taking their values in infinite dimensional spaces rather than standard vectors. This fact has complex consequences on data analysis algorithms that motivate modifications of them.
Aronszajn +40 more
core +7 more sources
Bio-Protocol, 2019 Until recently, whole-proteome microarrays for comprehensive studies of protein interactions were mostly produced by individual cloning and cellular expression of very many open reading frames, followed by protein isolation and purification as well as ...
Katrin Hufnagel +8 more
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Functional analysis on two-dimensional local fields
, 2013 We establish how a two-dimensional local field can be described as a locally convex space once an embedding of a local field into it has been fixed. We study the resulting spaces from a functional analytic point of view: in particular we study bounded, c-
Camara, Alberto
core +1 more source
Broken Symmetry in Density-Functional Theory: Analysis and Cure [PDF]
, 2003 We present a detailed analysis of the broken-symmetry mean-field solutions using a four-electron rectangular quantum dot as a model system. Comparisons of the density-functional theory predictions with the exact ones show that the symmetry breaking ...
A. Harju +16 more
core +2 more sources