Results 41 to 50 of about 3,444,674 (308)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Plasma Proteomic Analysis Identified Proteins Associated with Faulty Neutrophils Functionality in Decompensated Cirrhosis Patients with Sepsis [PDF]

, 2022
Rashi Sehgal, Navkiran Kaur, Rakhi Maiwall, Gayatri Ramakrishna, Jaswinder Singh Maras, Nirupma Trehanpati   +5 more
openalex   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An in-depth evaluation of sample and measurement induced influences on static contact angle measurements

Scientific Reports, 2022
Static contact angle measurements are one of the most popular methods to analyze the wetting behavior of materials of any kind. Although this method is readily applicable without the need of sophisticated machinery, the results obtained for the very same
Sarah Marie Lößlein, Rolf Merz, Daniel Wyn Müller, Michael Kopnarski, Frank Mücklich   +4 more
doaj   +1 more source

Predicting response to tVNS in patients with migraine using functional MRI: A voxels-based machine learning analysis [PDF]

, 2022
Chengwei Fu, Yue Zhang, Yongsong Ye, Xiaoyan Hou, Zeying Wen, Zhaoxian Yan, Wenting Luo, Menghan Feng, Bo Liu   +8 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

An integrated experimental and analytical approach for the analysis of the mechanical interaction between metal porous scaffolds and bone: implications for stress shielding in orthopedic implants

Frontiers in Bioengineering and Biotechnology
IntroductionMetal porous structures are becoming a standard design feature of orthopedic implants such as joint endoprostheses. The benefits of the pores are twofold: 1) help improve the cementless primary stabilization of the implant by increasing ...
Roberto Ramaglia Amadasi, Giulia Rogati, Erica Liverani, Alberto Leardini, Paolo Caravaggi   +4 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Functional genomics of the human epididymis: Further characterization of efferent ducts and model systems by single‐cell RNA sequencing analysis [PDF]

, 2023
Shih‐Hsing Leir, Alekh Paranjapye, Ann Harris   +2 more
openalex   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source