Results 111 to 120 of about 1,429,229 (267)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multilevel Genetic and Functional Assessment of an ARR3 Frameshift Variant in Early-Onset High Myopia. [PDF]

Int J Genomics
Li Y, Teng F, Zhu Q, Cui S, Yang W, Ma P.   +5 more
europepmc   +1 more source

THE ASSESSMENT OF PULMONARY FUNCTION

British Journal of Anaesthesia, 1962
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Multimodal Functional Assessment of Asymmetries in Youth Soccer Players: Study Protocol. [PDF]

Life (Basel)
Codreanu AM, Korodi DA, Lupu NA, Onciulenco AV, Vataman AA, Duse AO, Rezumes MZ, Amaricai EC, Catan L, Caraba A, Onofrei RR, Borza C.   +11 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Reliability and Validity Study of the International Classification of Functioning，Disability and Health Rehabilitation Set in Rehabilitation of Knee Osteoarthritis

康复学报
ObjectiveTo explore the reliability and validity of the International Classification of Functioning, Disability and Health Rehabilitation Set (ICF-RS) in assessing the body function, activities and social participation of patients with knee ...
LEI Lei, PENG Zhizhou, GAO Mingyue, LI Fei, MAO Ningning, WU Xi, XIAO Chengcheng, XUN Yajing, ZHAO Suchen, FAN Xiaojun   +9 more
doaj  

Linking the Pre-Assessment Information Form (PIF) to the ICF: Enhancing Standardized Functional Assessment in Parkinson's Disease. [PDF]

Physiother Res Int
Rogatto FBT, Guelfi ÉTN, Alflen VEV, Silva LBB, Pereira GS, Silva SM.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The Assessment of Platelet Function [PDF]

Postgraduate Medical Journal, 1959
openaire   +2 more sources