Results 61 to 70 of about 1,429,229 (267)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Relationships between selected elements of physical and functional fitness and the competitive performance of judo athletes

Revista de Artes Marciales Asiáticas
Judo competitors at the highest sports skill level are characterized by a high level of physical fitness, mental toughness, and technical skills developed through years of training.
Dariusz Boguszewski
doaj   +1 more source

Electromyographic Activity of the Upper Limb in Three Hand Function Tests

Hong Kong Journal of Occupational Therapy, 2017
Objective/Background: Occupational therapists usually assess hand function through standardised tests, however, there is no consensus on how the scores assigned to hand dexterity can accurately measure hand function required for daily activities and few ...
Natália Sanches Silva, Pedro Henrique Tavares Queiroz de Almeida, Paulo Vinícius Braga Mendes, Caio Sadao Medeiros Komino, José Marques Novo Jùnior, Daniel Marinho Cezar Da Cruz   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Case Report: Fabrication of a plumper-type music splint for saxophone performance in a patient with a full-arch implant-supported prosthesis

Frontiers in Dental Medicine
IntroductionThe orofacial region, particularly the lips, tongue, and teeth, plays a critical role in wind instrument performance. Wind instrument players may experience lip pain, trauma, or discomfort during performance.
Mariko Hattori, Yuichi Yamatani, Yuka Sumita, Yuka Sumita, Noriyuki Wakabayashi   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Editorial: Tools and strategies that promote the return to work and stay at work of people with disabilities—contributions from occupational therapy and other disciplines centered on the biopsychosocial approach

Frontiers in Rehabilitation Sciences, 2023
Edda Capodaglio, Enrico Oddone
doaj   +1 more source

Tactile sensation moderates the association between hand dexterity and higher-level cognition in older adults with and without MCI

Frontiers in Aging Neuroscience
BackgroundTactile sensation and hand dexterity decline with age and are associated with later-life cognition, yet it remains unclear whether tactile sensation moderates the strength of hand motor–cognitive associations.
Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Susumu Ogawa, Hiroko Matsunaga, Keigo Hinakura, Shun Yoshikoshi, Shun Yoshikoshi, Yan Li, Maki Nishinakagawa, Hiroyuki Suzuki   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source