Results 101 to 110 of about 3,210,715 (302)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Personal technology and the calculus [PDF]
, 1998 The calculus has long been seen as the pinnacle of mathematical endeavour in secondary schools, and rightly so. For as long as most of can remember, algebra and calculus have formed the trunk of mathematics, without which students can progress no further.
Kissane, B.
core
The differential calculus of causal functions
CoRR, 2019 Causal functions of sequences occur throughout computer science, from theory to hardware to machine learning. Mealy machines, synchronous digital circuits, signal flow graphs, and recurrent neural networks all have behaviour that can be described by causal functions.
David Sprunger, Bart Jacobs 0001
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Can female urethral calculus present with acute urinary retention?
Formosan Journal of Surgery, 2018 Urethral calculus is a very rare cause obstructive uropathy. Incidence of urethral calculus is extremely rare, less often in females as compared to males. It is usually associated with genitourinary pathology.
M Mahele +3 more
doaj +1 more source
Functional Calculus for Dual Quaternions
Advances in Applied Clifford Algebras, 2023 We give a formula for $f(η)$, where $f :\mathbb C \to \mathbb C$ is a continuously differentiable function satisfying $f(\bar z) = \overline{f(z)}$, and $η$ is a dual quaternion. Note this formula is straightforward or well known if $η$ is merely a dual number or a quaternion.
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Electronic Journal of Differential Equations, 2012 This work is devoted to the study of a complete abstract second-order differential equation of elliptic type with variable operators as coefficients.
Fatiha Boutaous +2 more
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