Results 101 to 110 of about 26,719 (309)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On conservativity of concurrent Haskell
, 2011 The calculus CHF models Concurrent Haskell extended by concurrent, implicit futures. It is a process calculus with concurrent threads, monadic concurrent evaluation, and includes a pure functional lambda-calculus which comprises data constructors, case ...
Sabel, David +3 more
core
A maximal theorem for holomorphic semigroups. [PDF]
, 2004 Let X be a closed linear subspace of the Lebesgue space L^p(Omega ; mu); let -A be an invertible linear operator that is the generator of abounded holomorphic semigroup T_t on X.
Ian Doust +3 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
On equivalences and standardization in a non-deterministic call-by-need lambda calculus
, 2007 The goal of this report is to prove correctness of a considerable subset of transformations w.r.t. contextual equivalence in a an extended lambda-calculus with case, constructors, seq, let, and choice, with a simple set of reduction rules. Unfortunately,
Mann, Matthias +3 more
core
Type−Directed Weaving of Aspects for Higher−order Functional Languages [PDF]
, 2006 Aspect-oriented programming (AOP) has been shown to be a useful model for software development. Special care must be taken when we try to adapt AOP to strongly typed functional languages which come with features like a type inference mechanism ...
Chen, Kung +9 more
core +1 more source
Thermodynamics Beyond Molecules: Statistical Thermodynamics of Probability Distributions
Entropy, 2019 Statistical thermodynamics has a universal appeal that extends beyond molecular systems, and yet, as its tools are being transplanted to fields outside physics, the fundamental question, what is thermodynamics, has remained unanswered.
Themis Matsoukas
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
On q-double modified Laplace transform [PDF]
Mathematics and Computational SciencesThe Laplace transform is widely used in science and technology to deal with complex problemsin stability and control systems. The modified Laplace transform has been applied in physics andmathematics to solve boundary layer equations in ordinary ...
Srikumar Panda +2 more
doaj +1 more source