Results 101 to 110 of about 203,888 (281)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Thermodynamics Beyond Molecules: Statistical Thermodynamics of Probability Distributions

Entropy, 2019
Statistical thermodynamics has a universal appeal that extends beyond molecular systems, and yet, as its tools are being transplanted to fields outside physics, the fundamental question, what is thermodynamics, has remained unanswered.
Themis Matsoukas
doaj   +1 more source

Functional calculus for noncommuting operators.

Michigan Mathematical Journal, 1995
Let \(F^2(H_n)={\mathbf C}1\oplus \bigoplus_{m\geq 1} H_n^{\otimes m}\) be the Fock space. \({\mathcal P}\) denotes the set of all \(p\in F^2(H_n)\) of the form: \(p=a_0+\sum a_{i_1\dots i_k} e_{i_1}\otimes\cdots\otimes e_{i_k}\), \(1\leq i_1,\dots, i_k\leq n\) and \(1\leq k\leq m\) where \(a_0,a_{i_1\dots i_k}\in{\mathbf C}\) and \(\{e_1,\dots, e_n\}\)
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

On q-double modified Laplace transform [PDF]

Mathematics and Computational Sciences
The Laplace transform is widely used in science and technology to deal with complex problemsin stability and control systems. The modified Laplace transform has been applied in physics andmathematics to solve boundary layer equations in ordinary ...
Srikumar Panda, Praveen Agarwal, Arvind Kumar Sinha   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Conditional Probability, Three-Slit Experiments, and the Jordan Algebra Structure of Quantum Mechanics

Advances in Mathematical Physics, 2012
Most quantum logics do not allow for a reasonable calculus of conditional probability. However, those ones which do so provide a very general and rich mathematical structure, including classical probabilities, quantum mechanics, and Jordan algebras. This
Gerd Niestegge
doaj   +1 more source

Spectral calculations on locally convex vector spaces I

, 2012
We develop a holomorphic functional calculus for (multivalued linear) operators on locally convex vector spaces.
Lakos, Gyula
core