Results 121 to 130 of about 4,689,287 (347)

Conditional Probability, Three-Slit Experiments, and the Jordan Algebra Structure of Quantum Mechanics

open access: yesAdvances in Mathematical Physics, 2012
Most quantum logics do not allow for a reasonable calculus of conditional probability. However, those ones which do so provide a very general and rich mathematical structure, including classical probabilities, quantum mechanics, and Jordan algebras. This
Gerd Niestegge
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

A Direct Approach to Shape Optimisation of Structures

open access: yesEngineering Transactions, 1979
Shape optimisation of structures constitutes - mathematically a non-standard problem of the calculus of variations consisting in searching for the conditional extremum of a functional which does not possess, as a rule, a "localization property".
Z.K. Leśniak
doaj  

A Fluent Calculus Approach to Automatic Web Service Composition

open access: yesAdvances in Electrical and Computer Engineering, 2009
Web service composition is mandatory when complex functional requirements cannot be satisfied by a single Web service. Because of the exponential growth of available Web services, their automatic discovery and composition are highly desirable tasks. This
CHIFU, V., SALOMIE, I.
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Numerical Approximations and Fractional Calculus: Extending Boole’s Rule with Riemann–LiouvilleFractional Integral Inequalities

open access: yesFractal and Fractional
This paper develops integral inequalities for first-order differentiable convex functions within the framework of fractional calculus, extending Boole-type inequalities to this domain. An integral equality involving Riemann–Liouville fractional integrals
Abdul Mateen   +4 more
doaj   +1 more source

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