Results 71 to 80 of about 26,719 (309)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Weak Eigenvectors and the Functional Calculus [PDF]
Transactions of the American Mathematical Society, 1963 In this paper we are concerned with the problem of constructing the functional calculus for an operator with continuous spectrum from a given collection of weak eigenvectors. A functional calculus is a homomorphism f-+ Tf of an algebra of functions defined over the 'spectrum' V into a subalgebra of bounded linear operators acting in a banach space E ...
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Functional calculus for generators of analytic semigroups of operators
Karpatsʹkì Matematičnì Publìkacìï, 2012 We construct a functional calculus for generators of one-parameter boundedanalytic semigroups of operators on a Banach space. The calculus symbol classconsist of the Laplace image of the convolution algebra $cal S'_+$ of tempereddistributions with ...
Lopushansky O.V., Sharyn S.V.
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2003 This paper proposes a non-standard way to combine lazy functional languages with I/O. In order to demonstrate the usefulness of the approach, a tiny lazy functional core language FUNDIO , which is also a call-by-need lambda calculus, is investigated. The
Schmidt-Schauß, Manfred
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Map Calculus in GIS: a proposal and demonstration
, 2004 This paper provides a new representation for fields (continuous surfaces) in Geographical Information Systems (GIS), based on the notion of spatial functions and their combinations.
Haklay, M
core
A calculus of functional BSP programs
Science of Computer Programming, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Frédéric Loulergue +2 more
openaire +1 more source