Results 91 to 100 of about 5,493,007 (396)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Altered resting-state functional connectivity of the frontal-striatal reward system in social anxiety disorder.

PLoS ONE, 2015
We investigated differences in the intrinsic functional brain organization (functional connectivity) of the human reward system between healthy control participants and patients with social anxiety disorder.
Joshua Manning, Gretchen Reynolds, Zeynep M Saygin, Stefan G Hofmann, Mark Pollack, John D E Gabrieli, Susan Whitfield-Gabrieli   +6 more
doaj   +1 more source

A Longitudinal Study of Changes in Resting-State Functional Magnetic Resonance Imaging Functional Connectivity Networks During Healthy Aging

Brain Connectivity, 2020
BACKGROUND Vast increases in life expectancy over the last century have led to shifts in population demographics and the emergence of a largely aged population, globally.
Meike Oschmann, J. Gawryluk
semanticscholar   +1 more source

Mapping functional connectivity

Ecological Indicators, 2009
An objective and reliable assessment of wildlife movement is important in theoretical and applied ecology. The identification and mapping of landscape elements that may enhance functional connectivity is usually a subjective process based on visual interpretations of species movement patterns.
Vogt, Peter, Ferrari, Joseph R., Lookingbill, Todd R., Gardner, Robert H., Riitters, Kurt H., Ostapowicz, Katarzyna   +5 more
openaire   +3 more sources

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis. [PDF]

PLoS ONE, 2013
The relation between pathological findings and clinical and cognitive decline in Multiple Sclerosis remains unclear. Here, we tested the hypothesis that altered functional connectivity could provide a missing link between structural findings, such as ...
Prejaas Tewarie, Menno M Schoonheim, Cornelis J Stam, Marieke L van der Meer, Bob W van Dijk, Frederik Barkhof, Chris H Polman, Arjan Hillebrand   +7 more
doaj   +1 more source

Abnormal resting-state functional connectivity in progressive supranuclear palsy and corticobasal syndrome [PDF]

, 2017
Background: Pathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between brain areas. Few studies have investigated resting-state functional connectivity (rsFC) in progressive
Berardelli, Alfredo, Bharti, Komal, Bologna, Matteo, Giannã¬, Costanza, Pantano, Patrizia, Petsas, Nikolaos, Piattella, Maria Cristina, Suppa, Antonio, Tona, Francesca, Upadhyay, Neeraj   +9 more
core   +2 more sources

Bacterial protein interaction networks: connectivity is ruled by gene conservation, essentiality and function [PDF]

, 2020
Protein-protein interaction (PPI) networks are the backbone of all processes in living cells. In this work we relate conservation, essentiality and functional repertoire of a gene to the connectivity $k$ of the corresponding protein in the PPI networks ...
Cimini, Giulio, Dilucca, Maddalena, Giansanti, Andrea   +2 more
core   +2 more sources

A Tutorial Review of Functional Connectivity Analysis Methods and Their Interpretational Pitfalls

Frontiers in Systems Neuroscience, 2016
Oscillatory neuronal activity may provide a mechanism for dynamic network coordination. Rhythmic neuronal interactions can be quantified using multiple metrics, each with their own advantages and disadvantages.
A. Bastos, J. Schoffelen
semanticscholar   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source