Results 81 to 90 of about 302,708 (266)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain

Frontiers in Pain Research
IntroductionThis study aims to investigate the interregional functional connectivity in chronic back pain patients with widespread hyperalgesia, patients with localized back pain, and pain-free controls using stimulus-evoked high-density EEG recordings ...
George Kenefati, George Kenefati, Mika M. Rockholt, Mika M. Rockholt, Katherine Eisert, Qiaosheng Zhang, Qiaosheng Zhang, Deborah Ok, Deborah Ok, Christopher G. Gharibo, Lucia Daiana Voiculescu, Lisa V. Doan, Lisa V. Doan, Zhe Sage Chen, Zhe Sage Chen, Zhe Sage Chen, Zhe Sage Chen, Jing Wang, Jing Wang, Jing Wang, Jing Wang   +20 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality

Frontiers in Neural Circuits
Local and global functional connectivity densities (lFCD and gFCD, respectively), derived from functional magnetic resonance imaging (fMRI) data, represent the degree of functional centrality within local and global brain networks.
Taisuke Yatomi, Taisuke Yatomi, Dardo Tomasi, Hideaki Tani, Shinichiro Nakajima, Sakiko Tsugawa, Nobuhiro Nagai, Teruki Koizumi, Waki Nakajima, Mai Hatano, Hiroyuki Uchida, Takuya Takahashi   +11 more
doaj   +1 more source

Functional connectivity among spikes in low dimensional space during working memory task in rat. [PDF]

PLoS ONE, 2014
Working memory (WM) is critically important in cognitive tasks. The functional connectivity has been a powerful tool for understanding the mechanism underlying the information processing during WM tasks.
Mei Ouyang, Shuangyan Li, Xin Tian
doaj   +1 more source

Decoupling of brain function from structure reveals regional behavioral specialization in humans

, 2019
The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate.
Preti, Maria Giulia, Van De Ville, Dimitri   +1 more
core   +2 more sources

Electroencephalography (EEG)-Derived Markers to Measure Components of Attention Processing [PDF]

, 2017
Although extensively studied for decades, attention system remains an interesting challenge in neuroscience field. The Attention Network Task (ANT) has been developed to provide a measure of the efficiency for the three attention components ...
Anzolin, Alessandra, Astolfi, Laura, Cincotti, Febo, Mattia, Donatella, Pichiorri, Floriana, Riccio, Angela, Toppi, Jlenia   +6 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Increased Gray Matter Density and Functional Connectivity of the Pons in Restless Legs Syndrome

Nature and Science of Sleep, 2020
Zhexue Xu,1,2,* Tao Han,1,2,* Tian Li,3 Xiaodong Zhang,3 Zhaoyang Huang,1,2 Shuqin Zhan,1,2 Chunyan Liu,1,2 Jinping Xu,3 Yuping Wang1,2 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of ...
Xu Z, Han T, Li T, Zhang X, Huang Z, Zhan S, Liu C, Xu J, Wang Y   +8 more
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