Results 161 to 170 of about 63,859 (253)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Microbiota-A Rescuing Modulator in Children Struggling with Functional Constipation. [PDF]

Microorganisms
Tomșa NA, Meliț LE, Popescu T, Najjar K, Văsieșiu AM, Pop AV, Borka-Balas R.   +6 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

The role of intestinal gases in pediatric functional constipation: a narrative review of pathophysiology and emerging therapeutics. [PDF]

Front Nutr
Zhou Y, Tao E.
europepmc   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

Influences of transcutaneous neuromodulation on fecal microbiota and short chain fatty acids in patients with functional constipation. [PDF]

BMC Gastroenterol
Zhang S, Shi H, Liu B, Ge Z, Zhang N, Liu Q, Duan Z, Chang Q.   +7 more
europepmc   +1 more source

Prospective Trial on Tolerability and Efficacy of Adjuvant Nedaplatin Plus Docetaxel for Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
The flow of this trial and the treatment schedule of adjuvant chemotherapy with nedaplatin plus docetaxel for completely resected non‐small cell lung cancer (NSCLC) (A). The primary endpoint of this study was tolerability, assessed by the completion rate of the planned four chemotherapy cycles. As a result, it was 74.3%, exceeding that reported for the
Koji Teramoto, Ryosuke Kaku, Tomoyuki Igarashi, Masayuki Hashimoto, Shoji Kitamura, Makoto Motoishi, Yuji Suzumura, Satoru Sawai, Yataro Daigo, Jun Hanaoka   +9 more
wiley   +1 more source

Mobile app improves treatment of functional constipation in children: a randomized single-blind study. [PDF]

BMC Pediatr
Leszkowicz J, Nazar W, Wysokińska-Zakrzewska K, Zdun-Ryżewska A, Czadek-Asner P, Dettlaff-Dunowska M, Plata-Nazar K, Szlagatys-Sidorkiewicz A.   +7 more
europepmc   +1 more source

L‐VISP: LSTM Visualization for Interpretable Symptom Prediction in Patient Cohorts

Computer Graphics Forum, EarlyView.
L‐VISP is a human‐machine solution that uses visual analytics for LSTM modelling in clinical research. L‐VISP uses custom visual encodings to make multiple LSTM variants interpretable, supporting a full range of analysis, from understanding model operations and evaluating performance to interpreting results in a clinical context.
C. Floricel, Y. Wang, A. Wentzel, C. D. Fuller, G. E. Marai, M. E. Papka, G. Canahuate   +6 more
wiley   +1 more source